全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Annemie Rutten , Patricia Soetekouw ...
来源:[J].Advances in Therapy(IF 2.125), 2015, Vol.32 (6), pp.510-522Springer
摘要:Abstract(#br) Background(#br)The oral, potent poly(ADP-ribose) polymerase (PARP) inhibitor, olaparib, is well tolerated at doses of ≤400 mg twice daily (BID) (administered as capsules), and has shown efficacy in patients with advanced BRCA -mutated ovarian and breast cancer....
作者:Annemie Rutten , Wendy Onstenk ...
来源:[J].Cancer Letters(IF 4.258), 2015, Vol.356 (2), pp.872-879Elsevier
摘要:Abstract(#br)We have shown that in up to half of the patients with metastatic breast cancer (MBC), higher numbers of circulating tumour cells (CTCs) are present in the central venous blood (CVB) compared to the peripheral venous blood (PVB), suggesting that the lungs might retain...
作者:... Laure-Anne Teuwen , Annemie Rutten , Luc Dirix
来源:[J].Expert Opinion on Biological Therapy(IF 3.345), 2015, Vol.15 (5), pp.749-760Taylor & Francis
摘要:Introduction:(#br) Ado- trastuzumab emtansine (T-DM1) is a human epidermal growth factor receptor 2 (HER2)-targeted antibody-drug conjugate composed of trastuzumab, a stable linker (MCC), and the cytotoxic agent DM1 (derivative of maytansine; mertansine). T-DM1 retains the mechan...
作者:Annemie Rutten , Francisco J. Carapeto ...
来源:[J].Journal of Cutaneous Pathology(IF 1.766), 2015, Vol.42 (10), pp.699-711Wiley
摘要:Background(#br)Many observational studies investigated the prognostic significance of angiogenesis and lymphangiogenesis in patients with melanoma. However, the obtained results are rather contradictory, probably due to the lack of the consensus methodology.(#br)Methods(#br)...
作者:... Laure-Anne Teuwen , Annemie Rutten , Luc Dirix
来源:[J].Expert Opinion on Biological Therapy(IF 3.345), 2015, Vol.15 (5), pp.749-760Informa Healthcare
摘要:Introduction: Ado- trastuzumab emtansine (T-DM1) is a human epidermal growth factor receptor 2 (HER2)-targeted antibody-drug conjugate composed of trastuzumab, a stable linker (MCC), and the cytotoxic agent DM1 (derivative of maytansine; mertansine). T-DM1 retains the mechanisms ...
作者:Annemie Rutten , Philippe Huget
来源:[J].Expert Opinion on Biological Therapy(IF 3.345), 2013, Vol.13 (4), pp.607-614Informa Healthcare
摘要:Introduction: Trastuzumab emtansine (T-DM1) is a human epidermal growth factor receptor 2 (HER2)–targeted antibody–drug conjugate (ADC) composed of trastuzumab, a stable linker (MCC), and the cytotoxic agent DM1 (derivative of maytansine). Administration of T-DM1 leads to li...
作者:Luc Dirix , Annemie Rutten
来源:[J].Future Oncol.(IF 3.202), 2012, Vol.8 (8), pp.915-928Future Science Group
摘要:Hedgehog pathway signaling is important for embryonic development; however, inappropriate reactivation of this pathway in adults has been linked to several forms of cancer. Vismodegib (Erivedge™), a first-in-class hedgehog pathway inhibitor, blocks the pathway by inhibiting...

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