全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Annelaure Damont , Frédéric Dollé ...
来源:[J].Molecular Imaging and Biology(IF 3.095), 2017, Vol.19 (5), pp.736-745Springer
摘要:Many neurological conditions result in the overexpression of the translocator protein 18 kDa (TSPO), today recognized as a biomarker for microglial activation and neuroinflammation imaging. The pyrazolo[1,5-a]pyrimidine acetamides are a particularly attractive class of TSPO-speci...
作者:... Frank Marguet , Frédéric Puech , Annelaure Damont
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2017, Vol.125, pp.346-359Elsevier
摘要:Abstract(#br)The translocator protein 18 kDa (TSPO) is today a validated target for a number of therapeutic applications, but also a well-recognized diagnostic/imaging biomarker for the evaluation of inflammatory related-disease state and progression, prompting the developme...
作者:Annelaure Damont , Sébastien Goutal ...
来源:[J].The AAPS Journal(IF 4.386), 2013, Vol.15 (4), pp.1082-1090Springer
摘要:Abstract(#br)Glyburide (glibenclamide, GLB) is a widely prescribed antidiabetic with potential beneficial effects in central nervous system injury and diseases. In vitro studies show that GLB is a substrate of organic anion transporting polypeptide (OATP) and ATP-binding cas...
作者:Annelaure Damont , Sébastien Goutal ...
来源:[J].European Journal of Pharmaceutical Sciences(IF 2.987), 2016, Vol.91, pp.98-104Elsevier
摘要:Abstract(#br)Cyclosporin A (CsA) and dipyridamole (DPy) are potent inhibitors of the P-glycoprotein (P-gp; ABCB1) in vitro . Their efficacy at inhibiting P-gp at the blood-brain barrier (BBB) is difficult to predict. Efficient and readily available ( i.e. marketed) P-gp inhi...
作者:Annelaure Damont , Frank Marguet ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2015, Vol.101, pp.736-745Elsevier
摘要:Abstract(#br)SSR180575 ( 1 ) is a high-affinity (0.83 nM) TSPO 18 kDa ligand belonging to the pyridazino[4,5- b ]indole-1-acetamides family. Herein we describe the synthesis and in vitro characterization of two series of new fluorinated analogues. Eleven compounds (out of fi...
作者:Annelaure Damont , Marie-Anne Peyronneau ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2014, Vol.24 (6), pp.1550-1556Elsevier
摘要:Abstract(#br)A series of four novel analogues of DPA-714, bearing a fluoroalkynyl side chain (with a length ranging from three to six carbon atoms) in replacement of the fluoroethoxy motif, have been synthetized in six steps from commercially available methyl 4-iodobenzoate....
作者:Annelaure Damont , David Dukhan ...
来源:[J].Nucleosides, Nucleotides and Nucleic Acids(IF 0.713), 2007, Vol.26 (10-12), pp.1431-1434Taylor & Francis
摘要:In search for new antiviral agents, we have been interested in 1'-C-fluoromethyl branched ribonucleosides. In this paper, we describe the synthesis of 1'-C-fluoromethyladenosine via electrophilic fluorination of exo-glycal.
作者:Annelaure Damont , Raphaël Boisgard ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2011, Vol.21 (16), pp.4819-4822Elsevier
摘要:Abstract(#br)6-Fluoro-PBR28 ( N -(6-fluoro-4-phenoxypyridin-3-yl) -N -(2-methoxybenzyl)acetamide), a fluorinated analogue of the recently developed TSPO 18 kDa ligand PBR28, was synthesized and labelled with fluorine-18. 6-Fluoro-PBR28 and its 6-chloro/6-bromo counterparts w...
作者:... Markus Bacher , Annelaure Damont , Andrea Steck
来源:[J].Tetrahedron Letters(IF 2.397), 2003, Vol.45 (3), pp.549-551Elsevier
摘要:Abstract(#br)Within the binding domain, ascomycin features the unusual pattern of a masked tricarbonyl moiety, which potentially allows for high structural diversity via simple isomerisation events. A cascade of diastereoselective rearrangement reactions at the binding domain, al...
作者:Annelaure Damont , Françoise Hinnen ...
来源:[J].Applied Radiation and Isotopes(IF 1.179), 2011, Vol.70 (3), pp.489-497Elsevier
摘要:Abstract(#br)Imaging of TSPO 18 kDa with PET is more and more considered as a relevant biomarker of inflammation in numerous diseases. Development of new radiotracers for TSPO 18 kDa has seen acceleration in the last years and the challenge today is to make available large amount...

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