全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Edith Hamel , Jan-Eric Ahlfors , Andrea C. LeBlanc
来源:[J].Molecular Neurodegeneration(IF 4.007), 2017, Vol.12 (1)Springer
摘要:The activation of the aspartate-specific cysteinyl protease, Caspase-6, is proposed as an early pathogenic event of Alzheimer disease (AD) and Huntington’s disease. Caspase-6 inhibitors could be useful against these neurodegenerative diseases but most Caspase-6 inhibitors ha...
作者:... Steffen Albrecht , David A. Bennett , Andrea C. LeBlanc
来源:[J].Neurobiology of Aging(IF 6.166), 2013, Vol.34 (7), pp.1815-1824Elsevier
摘要:Abstract(#br)Caspase-6 (Casp6), a cysteinyl protease that induces axonal degeneration, is activated early in Alzheimer Disease (AD) brains. To determine whether Casp6 activation is responsible for early cognitive impairment, we investigated the abundance of Casp6 activity, p...
作者:... Tracy Petzke , Catherine Bergeron , Andrea C. LeBlanc
来源:[J].The American Journal of Pathology(IF 4.522), 2004, Vol.165 (2), pp.523-531Elsevier
摘要:Previously, we have shown that caspase-6 but not caspase-3 is activated by serum deprivation and induces a protracted cell death in primary cultures of human neurons (LeBlanc AC, Liu H, Goodyer C, Bergeron C, Hammond J: Caspase-6 role in apoptosis of human neurons, amyloidog...

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