全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Anand Goswami , Richard Zimmermann ...
来源:[J].Acta Neuropathologica(IF 9.734), 2014, Vol.127 (5), pp.761-777Springer
摘要:Abstract(#br)Marinesco–Sjögren syndrome (MSS) features cerebellar ataxia, mental retardation, cataracts, and progressive vacuolar myopathy with peculiar myonuclear alterations. Most MSS patients carry homozygous or compound heterozygous SIL1 mutations. SIL1 is a nucleotide e...
作者:Anand Goswami , Audrey Filézac de L’Etang ...
来源:[J].Acta Neuropathologica(IF 9.734), 2016, Vol.131 (3), pp.427-451Springer
摘要:Abstract(#br)Amyotrophic lateral sclerosis (ALS) is an adult onset progressive motor neuron disease with no cure. Transgenic mice overexpressing familial ALS associated human mutant SOD1 are a commonly used model for examining disease mechanisms. Presently, it is well accept...
作者:Anand Goswami , Priyanka Dikshit ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2006, Vol.342 (1), pp.184-190Elsevier
摘要:Abstract(#br)Huntington’s disease (HD) is a familial neurodegenerative disorder caused by an abnormal expansion of CAG repeats in the coding region of huntingtin gene. A major hallmark of HD is the proteolytic production of N-terminal fragments of huntingtin containing polyg...
作者:Anand Goswami , Amit Mishra ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2006, Vol.342 (4), pp.1323-1328Elsevier
摘要:Abstract(#br)Formation of neuronal intranuclear inclusions of the disease proteins that are ubiquitinated and often associated with various proteasome components is the major hallmark of the polyglutamine diseases. Curcumin is a polyphenolic compound having anti-inflammatory...
作者:Anand Goswami , Kay Nolte ...
来源:[J].Neoplasia, 2014, Vol.16 (3), pp.207-220.e4Elsevier
摘要:Abstract(#br)Overexpression of the epidermal growth factor receptor (EGFR) is observed in a large number of neoplasms. The monoclonal antibody cetuximab/Erbitux is frequently applied to treat EGFR-expressing tumors. However, the application of cetuximab alone or in combination wi...
作者:Anand Goswami , Christofer Marvin Jesse ...
来源:[J].Neuropathology and Applied Neurobiology(IF 4.837), 2015, Vol.41 (3), pp.304-318Wiley
摘要:Aim(#br)Upon denervation, skeletal muscle fibres initiate complex changes in gene expression. Many of these genes are involved in muscle fibre remodelling and atrophy. Amyotrophic lateral sclerosis ( ALS ) leads to progressive neurodegeneration and neurogenic muscular atroph...
作者:Anand Goswami , Tania Rizo ...
来源:[J].Glia(IF 5.066), 2015, Vol.63 (12), pp.2260-2273Wiley
摘要:Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of motoneurons in the cerebral cortex, brainstem and spinal cord. Neuroinflammation plays an important role in the pathogenesis of ALS and involves the activation of microglia and astrocytes. Intracellu...
作者:Anand Goswami , Joachim Weis ...
来源:[J].Neurology(IF 8.249), 2018Wolters Kluwer
摘要:OBJECTIVE: To isolate and identify a new, as yet unknown molecule in CSF that could serve as marker for Alzheimer disease. METHODS: We immunized mice with human CSF and fused hybridomas for monoclonal antibodies and screened these antibodies for their capacity to discriminat...

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