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作者:Ana Guzman-Aranguez , Pablo Argüeso
来源:[J].The Ocular Surface(IF 2.643), 2010, Vol.8 (1), pp.8-17Elsevier
摘要:Abstract(#br)Mucins are major components in mucus secretions and apical cell membranes on wet-surfaced epithelia. Structurally, they are characterized by the presence of tandem repeat domains containing heavily O-glycosylated serine and threonine residues. O-glycans contribute to...
作者:Ana Guzman-Aranguez , Maria Jesus Perez de Lara
来源:[J].Experimental Eye Research(IF 3.026), 2015, Vol.134, pp.141-147Elsevier
摘要:Abstract(#br)The effect of the dinucleotide P 1 , P 4 -Di (adenosine-5') tetraphosphate (Ap 4 A) in improving adrenergic anti-glaucomatous delivery by modifying the tight junction proteins of the corneal epithelium was evaluated. Stratified human corneal epithelial cells (HC...
作者:Ana Guzman-Aranguez , Maria J. Pérez de Lara ...
来源:[J].Progress in Retinal and Eye Research(IF 9.439), 2016, Vol.55, pp.182-205Elsevier
摘要:Abstract(#br)Dinucleoside polyphosphates comprises a group of dinucleotides formed by two nucleosides linked by a variable number of phosphates, abbreviated NpnN (where n represents the number of phosphates). These compounds are naturally occurring substances present in tears, aq...
作者:Ana Guzman-Aranguez , Laura María Díez ...
来源:[J].Experimental Eye Research(IF 3.026), 2012, Vol.101, pp.49-55Elsevier
摘要:Abstract(#br)The ability of diinosine polyphosphates, diinosine triphosphate (Ip 3 I), diinosine tetraphosphate (Ip 4 I) and diinosine pentaphosphate (Ip 5 I) to modify intraocular pressure in normotensive New Zealand white rabbits was tested. Ip 5 I produced increase in int...
作者:Ana Guzman-Aranguez , José Manuel González-Méijome
来源:[J].Journal of Optometry, 2013, Vol.6 (4), pp.205-211Elsevier
摘要:Abstract(#br)Purpose(#br)To evaluate the possible use of soft contact lenses (CL) to improve the secretagogue role of diadenosine tetraphosphate (Ap 4 A) promoting tear secretion.(#br)Methods(#br)Two conventional hydrogel CL (Omafilcon A and Ocufilcon D) and two silicone hyd...
作者:Ana Guzman-Aranguez , Patricia Loma
来源:[J].Experimental Eye Research(IF 3.026), 2013, Vol.113, pp.156-161Elsevier
摘要:Abstract(#br)Diadenosine polyphosphates are a type of dinucleotides that have been detected in rabbit and human tears. However, their origin and their mechanism of release have not been fully elucidated. In this work we investigated whether the dinucleotides Ap 4 A and Ap 5 ...
作者:Ana Guzman-Aranguez , Maria J. Perez de Lara ...
来源:[J].Data in Brief, 2019, Vol.25Elsevier
摘要:Abstract(#br)In vitro cytotoxicity and in vivo acute and 7 days repeat-dose ocular toxicity studies, were conducted in rabbits, in accordance with the Organisation for Economic Co-operation and Development (OECD) guidelines, for bimatoprost loaded nanovesicular aqueous dispe...

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