全部文献期刊会议图书|学者科研项目
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作者:Alexandra Paun , Christopher Yau , Jayne S. Danska
来源:[J].Journal of Autoimmunity(IF 8.145), 2016, Vol.71, pp.10-18
摘要:Abstract(#br)Type 1 diabetes (T1D) is an autoimmune disease resulting from T cell-mediated destruction of the insulin-secreting pancreatic beta cells. During the past 50 years T1D incidence has increased dramatically in many countries accompanied by an earlier age of onset e...
作者:Alexandra Paun , Jayne S Danska
来源:[J].Current Opinion in Immunology(IF 8.771), 2015, Vol.37, pp.34-39
摘要:The trillions of microorganisms populating the mammalian mucosal surfaces (i.e. the microbiome) participate in the development and function of the host immune system that acts to balance clearance of pathogens with tolerance of beneficial commensals. Recent advances in mucos...
作者:Alexandra Paun , Marie-Eve Bergeron , Christina K. Haston
来源:[J].Scientific Reports(IF 2.927), 2017, Vol.7 (1), pp.3991-4008
摘要:Abstract(#br)Radiotherapy can result in lung diseases pneumonitis or fibrosis dependent on patient susceptibility. Herein we used inbred and genetically altered mice to investigate whether the tissue adaptive immune response to radiation injury influences the development of ...
作者:Alexandra Paun , Veronika von Messling ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.6 (11)
摘要:Influenza A virus seasonal outbreaks and occasional pandemics represent a global health threat. The high genetic instability of this virus permits rapid escape from the host immune system and emergence of resistance to antivirals. There is thus an urgent need to develop novel app...
作者:Alexandra Paun , Jessica Fox ...
来源:[J].International Journal of Radiation Oncology, Biology, Physics(IF 4.524), 2010, Vol.77 (4), pp.1198-1205
摘要:Purpose(#br)To determine whether Toll-like receptor 2 or 4 genotype alters the lung response to irradiation in C57BL/6 mice using a model developing a phenotype that resembles radiotherapy-induced fibrosis in both histological characteristics and onset post-treatment.(#br)Methods...
作者:Alexandra Paun , Christina K. Haston
来源:[J].Radiotherapy and Oncology(IF 4.52), 2012, Vol.105 (3), pp.350-357
摘要:Abstract(#br)Background and purpose(#br)To identify genes which influence the fibrotic response to thoracic cavity radiotherapy, we combined a genome wide single nucleotide polymorphism (SNP) association evaluation of inbred strain response with prior linkage and gene expres...
作者:Mark Bazett , Alexandra Paun , Christina K. Haston
来源:[J].Molecular Genetics and Metabolism(IF 2.834), 2011, Vol.103 (1), pp.38-43
摘要:Abstract(#br)Cystic fibrosis (CF) intestinal disease is characterized by alterations in processes such as proliferation and apoptosis which are known to be regulated in part by microRNAs. Herein, we completed microRNA expression profiling of the intestinal tissue from the cy...
作者:Alexandra Paun , Amit Kunwar , Christina K Haston
来源:[J].Radiation Oncology(IF 2.107), 2015, Vol.10 (1)
摘要:Abstract(#br) Background(#br)The lung response to radiation exposure can involve an immediate or early reaction to the radiation challenge, including cell death and an initial immune reaction, and can be followed by a tissue injury response, of pneumonitis or fibrosis, to th...
作者:Alexandra Paun , Veronika von Messling ...
来源:[J].PLOS ONE(IF 3.73), 2011, Vol.6 (11)
摘要:Influenza A virus seasonal outbreaks and occasional pandemics represent a global health threat. The high genetic instability of this virus permits rapid escape from the host immune system and emergence of resistance to antivirals. There is thus an urgent need to develop novel app...

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