全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Alex B. Burgin , David Fox ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2014, Vol.24 (16), pp.4031-4034Elsevier
摘要:Abstract(#br)In this study we report a series of triazine derivatives that are potent inhibitors of PDE4B. We also provide a series of structure activity relationships that demonstrate the triazine core can be used to generate subtype selective inhibitors of PDE4B versus PDE...
作者:David Fox , Alex B. Burgin , Mark E. Gurney
来源:[J].Cellular Signalling(IF 4.304), 2014, Vol.26 (3), pp.657-663Elsevier
摘要:Abstract(#br)Phosphodiesterase-4B (PDE4B) regulates the pro-inflammatory Toll Receptor –Tumor Necrosis Factor α (TNFα) pathway in monocytes, macrophages and microglial cells. As such, it is an important, although under-exploited molecular target for anti-inflammatory drugs. ...
作者:Mark E. Gurney , Emily C. D’Amato , Alex B. Burgin
来源:[J].Neurotherapeutics(IF 5.904), 2015, Vol.12 (1), pp.49-56Springer
摘要:Abstract(#br)Between 20% and 25% of patients diagnosed with Alzheimer’s disease (AD) do not have amyloid burden as assessed by positron emission tomography imaging. Thus, there is a need for nonamyloid-directed therapies for AD, especially for those patients with non-amyloid...
作者:Alex B. Burgin , Vincent Manganiello
来源:[J].Cell(IF 31.957), 2012, Vol.148 (3), pp.421-433Elsevier
摘要:Summary(#br)Resveratrol, a polyphenol in red wine, has been reported as a calorie restriction mimetic with potential antiaging and antidiabetogenic properties. It is widely consumed as a nutritional supplement, but its mechanism of action remains a mystery. Here, we report t...
作者:Alex B. Burgin , Nassim Usman
来源:[J].Nucleosides, Nucleotides and Nucleic Acids(IF 0.713), 1997, Vol.16 (7-9), pp.955-958Taylor & Francis
摘要:The synthesis of all four phosphoramidites of 2'-O-methylthiomethyl ribonucleosides and their incorporation into hammerhead ribozymes and influence on nuclease stability and catalytic activity is described.
作者:Alex B. Burgin
来源:[J].Cell(IF 31.957), 1997, Vol.91 (7), pp.873-874Elsevier
作者:Alex B. Burgin,Jr , Howard A. Nash
来源:[J].Current Biology(IF 9.494), 1995, Vol.5 (11), pp.1312-1321Elsevier
摘要:Abstract(#br)Background: A fundamental feature of bacteriophage λ site-specific recombination is the strict requirement for a region of sequence identity between recombining DNA duplexes. It has been difficult to understand how the recombination machinery identifies and resp...
作者:Alex B. Burgin , Levi A. Garraway ...
来源:[J].Cell Reports, 2016, Vol.17 (4), pp.1171-1183Elsevier
摘要:Summary(#br)Tumor-specific genomic information has the potential to guide therapeutic strategies and revolutionize patient treatment. Currently, this approach is limited by an abundance of disease-associated mutants whose biological functions and impacts on therapeutic response a...
作者:... Bart Staker , Kathryn Hjerrild , Alex B. Burgin
来源:[J].Journal of Molecular Biology(IF 3.905), 2004, Vol.338 (5), pp.895-906Elsevier
摘要:Abstract(#br)Tyrosyl-DNA phosphodiesterase I (Tdp1) is involved in the repair of DNA lesions created by topoisomerase I in vivo . Tdp1 is a member of the phospholipase D (PLD) superfamily of enzymes and hydrolyzes 3′-phosphotyrosyl bonds to generate 3′-phosphate DNA and free...

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