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作者:Alejandro Martínez-Águila , María J. Pérez de Lara
来源:[J].Purinergic Signalling(IF 2.635), 2017, Vol.13 (2), pp.171-177
摘要:Glaucoma is a neurodegenerative disease that produces blindness. The main factor associated with this disease is an abnormally elevated intraocular pressure (IOP). To date, some attempts have been made to demonstrate the role of nucleotides modulating IOP, but never in a mod...
作者:Alejandro Martínez-Águila , Miguel Díaz-Hernández
来源:[J].Purinergic Signalling(IF 2.635), 2015, Vol.11 (1), pp.87-93
摘要:Abstract(#br)The purpose of this study is to investigate if the cholinergic stimulation by carbachol on tear secretion is a direct process or if it is also mediated by purinergic mechanisms. Experiments were performed in New Zealand male rabbits. The amount of tear secretion...
作者:Alejandro Martínez-Águila , Begoña Fonseca ...
来源:[J].European Journal of Pharmacology(IF 2.592), 2013, Vol.701 (1-3), pp.213-217
摘要:Abstract(#br)In the search for new compounds to reduce intraocular pressure (IOP), with fewer side effects, we have found that agomelatine, a melatonin analogue, can reduce IOP being, therefore, interesting for the treatment of ocular hypertension and glaucoma. In normotensi...
作者:Alejandro Martínez-Águila , Candela Rodriguez-Pomar ...
来源:[J].International Ophthalmology: The International Journal of Clinical Ophthalmology and Visual Sciences, 2020, Vol.40 (1), pp.419-422
摘要:Abstract(#br)Purpose(#br)To evaluate the effect of a new nutritional supplement based on melatonin on the intraocular pressure (IOP) in normotensive subjects. Patients and methods(#br)A short-term prospective study was designed. Sixty-seven normotensive subjects were recruit...
作者:Alejandro Martínez-Águila , Pilar Alarma-Estrany
来源:[J].Pharmacogenetics and Genomics(IF 3.608), 2011, Vol.21 (9), pp.587-589
摘要:We have demonstrated that 5-methoxycarbonylamino-N-acetyltryptamine (5-MCA-NAT), reduces intraocular pressure (IOP) in rabbits. In addition, we have reported a link between hypotensive effect of 5-MCA-NAT and sympathetic nervous system. Moreover, it is known that aqueous humour p...

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