全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Alecu I , Milenkova T , Turner SR
来源:[J].Drug Design, Development and Therapy(IF 3.486), 2018, Vol.Volume 12, pp.347-348DOAJ
摘要:Iulian Alecu, Tsveta Milenkova, Simon R Turner Research and Development, AstraZeneca UK Limited, Cambridge, UKThe tolerability profile of PARP inhibitors often includes hematologic toxicities, and the characterization of these adverse events is important to allow effective manage...
作者:Alecu I , Silva L C
来源:[J].Biochimica et biophysica acta. Molecular and cell biology of lipids, 2019PubMed
摘要:Sphingolipids (SLs) are fundamental components of eukaryotic cells. 1-Deoxysphingolipids differ structurally from canonical SLs as they lack the essential C1-OH group. Consequently, 1-deoxysphingolipids cannot be converted to complex sphingolipids and not degraded over the canoni...
作者:Alecu I , Fähndrich E ...
来源:[J].European journal of neurology, 2015, Vol.22 (5), pp.806-14, e55PubMed
摘要:Diabetic distal sensorimotor polyneuropathy (DSPN) is a frequent, disabling complication of diabetes mellitus. There is increasing evidence that sphingolipids play a role in insulin resistance and type 2 diabetes (T2DM). Whether neurotoxic 1-deoxy-sphingolipids are elevated ...

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