全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Arthur P. Arnold , Aldons J. Lusis , Karen Reue
来源:[J].BMC Genomics(IF 4.397), 2017, Vol.18 (1)Springer
摘要:MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression by targeting specific mRNA species for degradation or interfering with translation. Specific miRNAs are key regulators of adipogenesis, and are expressed at different levels in adipose tissue from...
作者:... Stanley L. Hazen , Markku Laakso , Aldons J. Lusis
来源:[J].Genome Biology, 2017, Vol.18 (1)Springer
摘要:The gut microbiome is a complex and metabolically active community that directly influences host phenotypes. In this study, we profile gut microbiota using 16S rRNA gene sequencing in 531 well-phenotyped Finnish men from the Metabolic Syndrome In Men (METSIM) study.
作者:Aldons J. Lusis , Samuli Ripatti ...
来源:[J].BMC Genomics(IF 4.397), 2016, Vol.17 (1)Springer
摘要:Abstract(#br) Background(#br)Complex diseases are characterized by multiple subtle perturbations to biological processes. New omics platforms can detect these perturbations, but translating the diverse molecular and statistical information into testable mechanistic hypotheses is ...
作者:Aldons J. Lusis , Rama Natarajan
来源:[J].Epigenetics & Chromatin(IF 4.19), 2016, Vol.9 (1)Springer
摘要:Abstract(#br) Background(#br)Functional regulatory regions in eukaryotic genomes are characterized by the disruption of nucleosomes leading to accessible chromatin. The modulation of chromatin accessibility is one of the key mediators of transcriptional regulation, and variation ...
作者:... Hooman Allayee , Aldons J. Lusis , Rick A. Friedman
来源:[J].G3: Genes, Genomes, Genetics(IF 1.794), 2016, Vol.6 (10), pp.3219-3228DOAJ
摘要:The discovery of environmentally specific genetic effects is crucial to the understanding of complex traits, such as susceptibility to noise-induced hearing loss (NIHL). We describe the first genome-wide association study (GWAS) for NIHL in a large and well-characterized pop...
作者:Aldons J. Lusis , Johanna Kuusisto ...
来源:[J].G3: Genes, Genomes, Genetics(IF 1.794), 2017, Vol.7 (9), pp.3217-3227DOAJ
摘要:Recent genome-wide association studies (GWAS) have identified variants associated with high-density lipoprotein cholesterol (HDL-C) located in or near the ANGPTL8 gene. Given the extensive sharing of GWAS loci across populations, we hypothesized that at least one shared vari...
作者:Aldons J. Lusis , Tom Michoel ...
来源:[J].Journal of the American College of Cardiology(IF 14.086), 2019, Vol.73 (23), pp.2946-2957Elsevier
摘要:Abstract(#br)Background(#br)Genetic variants currently known to affect coronary artery disease (CAD) risk explain less than one-quarter of disease heritability. The heritability contribution of gene regulatory networks (GRNs) in CAD, which are modulated by both genetic and e...

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