全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Balázs Győrffy , Peter Schirmacher , Albrecht Stenzinger
来源:[J].BMC Medical Genomics(IF 3.466), 2017, Vol.10 (1)Springer
摘要:Inhibition of the PD-L1/PD-1 immune checkpoint axis represents one of the most promising approaches of immunotherapy for various cancer types. However, immune checkpoint inhibition is successful only in subpopulations of patients emphasizing the need for powerful biomarkers that ...
作者:Albrecht Stenzinger , Niels Halama ...
来源:[J].BMC Cancer(IF 3.333), 2017, Vol.17 (1)Springer
摘要:Metastatic pancreatic cancer has a dismal prognosis, with a mean six-month progression-free survival of approximately 50% and a median survival of about 11 months. Despite intensive research, only slight improvements of clinical outcome could be achieved over the last decades. He...
作者:Albrecht Stenzinger , Volker Endris ...
来源:[J].Virchows Archiv(IF 2.676), 2017, Vol.471 (4), pp.509-520Springer
摘要:The European Commision (EC) recently approved osimertinib for the treatment of adult patients with locally advanced or metastatic non-small-cell lung cancer (NSCLC) harboring EGFR T790M mutations. Besides tissue-based testing, blood samples containing cell-free circulating tumor ...
作者:... Peter Schirmacher , Arne Warth , Albrecht Stenzinger
来源:[J].Diagnostic Pathology(IF 1.85), 2016, Vol.11 (1)Springer
摘要:Abstract(#br) Background(#br)Inhibition of the oncogenic fusion-gene EML4-ALK is a current first-line approach for patients with stage IV non-small cell lung cancer. While FISH was established as the gold standard for identifying these patients, there is accumulating evidence tha...
作者:Albrecht Stenzinger , Volker Budach
来源:[J].Journal of Translational Medicine(IF 3.459), 2015, Vol.13 (1)Springer
摘要:Abstract(#br) Background(#br)The mammalian target of rapamycin (mTOR) signaling pathway plays a pivotal role in numerous cellular processes involving growth, proliferation and survival. The purpose of this study was to investigate the anti-tumoral effect of the mTOR inhibitor (mT...
作者:... Peter E. Huber , Albrecht Stenzinger , Jürgen Debus
来源:[J].Radiation Oncology(IF 2.107), 2015, Vol.10 (1)Springer
摘要:Abstract(#br) Background(#br)Minimal improvements in treatment or survival of patients with osteosarcoma have been achieved during the last three decades. Especially in the case of incomplete tumor resection, prognosis remains poor. Heavy ion radiotherapy (HIT) and modern antican...
作者:Albrecht Stenzinger , Wilko Weichert ...
来源:[J].Radiation Oncology(IF 2.107), 2015, Vol.10 (1)Springer
摘要:Abstract(#br)The introduction of next-generation sequencing (NGS) in the field of cancer research has boosted worldwide efforts of genome-wide personalized oncology aiming at identifying predictive biomarkers and novel actionable targets. Despite considerable progress in understa...
作者:Albrecht Stenzinger , Eva K Roth ...
来源:[J].Journal of Translational Medicine(IF 3.459), 2015, Vol.13 (1)Springer
摘要:Abstract(#br) Background(#br)Osteosarcoma (OS) is the most common pediatric primary malignant bone tumor. As the prognosis for patients following standard treatment did not improve for almost three decades, functional preclinical models that closely reflect important clinical can...
作者:... Wilko Weichert , Jan Budczies , Albrecht Stenzinger
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (5)DOAJ
摘要:BACKGROUND: Autopsy rates in Western countries consistently decline to an average of <5%, although clinical autopsies represent a reasonable tool for quality control in hospitals, medically and economically. Comparing pre- and postmortal diagnoses, diagnostic discrepancies a...

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