全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:... Hayball John D , Garg Sanjay , Albrecht Hugo
来源:[J].International journal of nanomedicine(IF 3.463), 2018, Vol.13, pp.293-305PubMed
摘要:Prostate cancer cells frequently overexpress the gastrin-releasing peptide receptor, and various strategies have been applied in preclinical settings to target this receptor for the specific delivery of anticancer compounds. Recently, elastin-like polypeptide (ELP)-based self-ass...
作者:Albrecht Hugo , Sykes Matthew J.
来源:[J].Molecular Pharmacology, 2015, Vol.88 (2), pp.380-389The Royal Society
摘要:The Ras/Raf/MAPK and PI3K/Akt/mTOR pathways are key signaling cascades involved in the regulation of cell proliferation and survival, and have been implicated in the pathogenesis of several types of cancers, including acute myeloid leukemia (AML). The oncogenic activity of eIF4E ...
作者:Albrecht Hugo , Milne Robert
来源:[J].ACS medicinal chemistry letters(IF 3.311), 2019, Vol.10 (5), pp.786-791PubMed
摘要:Specific abrogation of cyclin-dependent kinase 5 (CDK5) activity has been validated as a viable approach for the development of anticancer agents. However, no selective CDK5 inhibitor has been reported to date. Herein, a structure-based in silico screening was employed to identif...
作者:Albrecht Hugo , Kübler Eric
来源:[J].Pharmaceutics, 2019, Vol.11 (9)PubMed
摘要:The use of many anticancer drugs is problematic due to severe adverse effects. While the recent clinical launch of several kinase inhibitors led to tremendous progress, these targeted agents tend to be of non-specific nature within the kinase target class. Moreover, target mediat...
作者:Albrecht Hugo , Zbinden Peter ...
来源:[J].Combinatorial chemistry & high throughput screening(IF 2), 2004, Vol.7 (8), pp.745-56PubMed
摘要:A cell-based assay using homogeneous time-resolved fluorescence has been developed for high throughput screening of putative beta-amyloid (Abeta)production inhibitors. In this assay, total Abeta is detected by simply adding two commercially available antibody complexes. The first...
作者:Albrecht Hugo , Song Yunmei
来源:[J].Journal of controlled release : official journal of the Controlled Release Society, 2019PubMed
摘要:Stents are currently the primary choice for the treatment of both vascular and non-vascular occlusions and/or stenosis. Despite the proven history of clinical safety and efficacy, the benefit of traditional vascular or non-vascular stenting is often limited by in-stent restenosis...
作者:Albrecht Hugo , Gerber Cobus ...
来源:[J].Bioorganic & medicinal chemistry letters, 2019, Vol.29 (18), pp.2650-2654PubMed
摘要:Post-translational modulation of eIF4E through phosphorylation by Mnks is highly integral to the pathogenesis of different cancers. Therefore, inhibition of Mnks offers a strategy for cancer treatment. Herein, a series of 2'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'-d...
作者:Albrecht Hugo , Song Yunmei
来源:[J].Journal of controlled release : official journal of the Controlled Release Society, 2019, Vol.308, pp.209-231PubMed
摘要:Stents are currently the primary choice for the treatment of both vascular and non-vascular occlusions and/or stenosis. Despite the proven history of clinical safety and efficacy, the benefit of traditional vascular or non-vascular stenting is often limited by in-stent restenosis...

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