全部文献期刊会议图书|学者科研项目
中外文文献  中文文献  外文文献
作者:Aki S Havulinna , Antti Jula ...
来源:[J].PLoS ONE(IF 3.73), 2018, Vol.7 (7)
摘要:Sudden cardiac death (SCD) accounts for up to half of cardiac mortality. The risk of SCD is heritable but the underlying genetic variants are largely unknown. We investigated whether common genetic variants predisposing to arrhythmia or related electrocardiographic phenotype...
作者:Aki S Havulinna , He Zhang ...
来源:[J].Nature Genetics(IF 35.209), 2016, Vol.48 (10), pp.1151-1161
摘要:Patricia Munroe, Joanna Howson and colleagues genotype ∼350,000 individuals and identify 30 new blood pressure– or hypertension-associated risk loci. Their analyses provide insights into the pathophysiology of hypertension and highlight new potential targets for clinical int...
作者:Aki S Havulinna , Christian Hengstenberg ...
来源:[J].Nature Genetics(IF 35.209), 2015, Vol.47 (6), pp.589-597
摘要:Samuli Ripatti and colleagues report the results of a genome-wide association study for circulating lipid levels based on 1000 Genomes Project imputation. Their results implicate several new loci, refine the association signals at many established loci and highlight the impact of...
作者:Aki S Havulinna , Frank Skorpen ...
来源:[J].PLoS Genetics(IF 8.694), 2011, Vol.7 (12)
摘要:Common genetic variants have been shown to explain a fraction of the inherited variation for many common diseases and quantitative traits, including height, a classic polygenic trait. The extent to which common variation determines the phenotype of highly heritable traits su...
作者:Aki S Havulinna , Priit Palta ...
来源:[J].PLoS Genetics(IF 8.694), 2014, Vol.10 (7)
摘要:Exome sequencing studies in complex diseases are challenged by the allelic heterogeneity, large number and modest effect sizes of associated variants on disease risk and the presence of large numbers of neutral variants, even in phenotypically relevant genes. Isolated popula...
作者:Aki S Havulinna , Matti Ketonen ...
来源:[J].BMC Cardiovascular Disorders(IF 1.457), 2007, Vol.7 (8), pp.1255-1259
摘要:Abstract(#br)Background(#br)Studies have suggested that the prevention and treatment of coronary heart disease may not have been as effective in women as in men. Therefore, we aimed to examine whether the incidence, attack rate and mortality of myocardial infarction (MI) eve...
作者:Aki S Havulinna , Johannes Hebebrand ...
来源:[J].Nature Genetics(IF 35.209), 2009, Vol.41 (Suppl. 4), pp.25-34
摘要:Joel Hirschhorn and colleagues report results of a large-scale genome-wide association and replication study for obesity-related traits. The newly discovered loci are enriched for genes expressed in the central nervous system, and may thus contribute to weight gain by modula...
作者:Aki S Havulinna , Björn Wahlstrand ...
来源:[J].Nature Genetics(IF 35.209), 2008, Vol.40 (2), pp.189-197
摘要:Abstract(#br)Blood concentrations of lipoproteins and lipids are heritable 1 risk factors for cardiovascular disease 2 , 3 . Using genome-wide association data from three studies ( n = 8,816 that included 2,758 individuals from the Diabetes Genetics In...
作者:Aki S Havulinna , Weang K Ho ...
来源:[J].Nature Genetics(IF 35.209), 2013, Vol.45 (1), pp.25-33
摘要:Panos Deloukas, Nilesh Samani and colleagues report a large-scale association analysis using the Metabochip array in 63,746 coronary artery disease cases and 130,681 controls. They identify 15 susceptibility loci, refine previous associations and use network analysis to highlight...
作者:Aki S Havulinna , Björn Wahlstrand ...
来源:[J].Nature Genetics(IF 35.209), 2008, Vol.40 (11), pp.1384-1384
摘要:Nat. Genet. 40, 189–197 (2008); published online 13 January 2008; corrected after print 29 October 2008 In the version of this article initially published, the institutional affiliation for Dolores Corella was not complete. Her affiliation is with the Department of Preventiv...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×