全部文献期刊会议图书|学者科研项目
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作者:Aik Choon Tan , Tsung Fei Khang
来源:[J].BMC Genomics(IF 4.397), 2017, Vol.18 (1)Springer
摘要:The drug discovery and development pipeline is a long and arduous process that inevitably hampers rapid drug development. Therefore, strategies to improve the efficiency of drug development are urgently needed to enable effective drugs to enter the clinic. Precision medicine has ...
作者:Karen A Ryall , Aik Choon Tan
来源:[J].Journal of Cheminformatics(IF 3.59), 2015, Vol.7 (1), pp.1-15Springer
摘要:Abstract(#br)Complex diseases like cancer are regulated by large, interconnected networks with many pathways affecting cell proliferation, invasion, and drug resistance. However, current cancer therapy predominantly relies on the reductionist approach of one gene-one disease. Com...
作者:... Lynn E Heasley , Jaewoo Kang , Aik Choon Tan
来源:[J].BMC Genomics(IF 4.397), 2015, Vol.16 (S12)Springer
摘要:Abstract(#br) Background(#br)Triple-Negative Breast Cancer (TNBC) is an aggressive disease with a poor prognosis. Clinically, TNBC patients have limited treatment options besides chemotherapy. The goal of this study was to determine the kinase dependency in TNBC cell lines and to...
作者:Aik Choon Tan , James H Resau
来源:[J].BMC Infectious Diseases(IF 3.025), 2011, Vol.11 (1)Springer
摘要:Abstract(#br) Background(#br) Salmonella enterica serovar Typhi ( S . Typhi) is a human-specific pathogen that causes typhoid fever, and remains a global health problem especially in developing countries. Its pathogenesis is complex and host response is poorly understood. In Afri...
作者:... Konstantin Rybnikov , Damon Berry , Aik Choon Tan
来源:[J].BMC Medical Genomics(IF 3.466), 2011, Vol.4 (1)Springer
摘要:Abstract(#br) Background(#br)Molecular classification of tumors can be achieved by global gene expression profiling. Most machine learning classification algorithms furnish global error rates for the entire population. A few algorithms provide an estimate of probability of malign...
作者:Aik Choon Tan , Wells A Messersmith ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (11)DOAJ
摘要:The activation of the MAPK and PI3K/AKT/mTOR pathways is implicated in the majority of cancers. Activating mutations in both of these pathways has been described in colorectal cancer (CRC), thus indicating their potential as therapeutic targets. This study evaluated the combinati...
作者:... Minji Jeon , Aik Choon Tan , Jaewoo Kang
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (7)DOAJ
摘要:Pathway analyses help reveal underlying molecular mechanisms of complex biological phenotypes. Biologists tend to perform multiple pathway analyses on the same dataset, as there is no single answer. It is often inefficient for them to implement and/or install all the algorithms b...

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