全部文献期刊会议图书|学者科研项目
中外文文献  中文文献  外文文献
作者:Jo-Anne de la Mare , Tamarin Jurgens , Adrienne L. Edkins
来源:[J].BMC Cancer(IF 3.333), 2017, Vol.17 (1)
摘要:Tumour metastasis remains the major cause of death in cancer patients and, to date, the mechanism and signalling pathways governing this process are not completely understood. The TGF-β pathway is the most commonly mutated pathway in cancer, however its role in cancer progre...
作者:... Heinrich C. Hoppe , Adrienne L. Edkins , Setshaba D. Khanye
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2020, Vol.187
摘要:Abstract(#br)Cancer and malaria remain relevant pathologies in modern medicinal chemistry endeavours. This is compounded by the threat of development of resistance to existing clinical drugs in use as first-line option for treatment of these diseases. To counter this threat,...
作者:... Jude M. Przyborski , Adrienne L. Edkins , Heinrich C. Hoppe
来源:[J].Scientific Reports(IF 2.927), 2020, Vol.10 (18), pp.347-358
摘要:Abstract(#br)The regulation of human Arf1 GTPase activity by ArfGEFs that stimulate GDP/GTP exchange and ArfGAPs that mediate GTP hydrolysis has attracted attention for the discovery of Arf1 inhibitors as potential anti-cancer agents. The malaria parasite Plasmodium falcipar...
作者:Adrienne L. Edkins , Michelle Isaacs ...
来源:[J].Journal of Inorganic Biochemistry(IF 3.197), 2017, Vol.172, pp.88-93
摘要:Abstract(#br)A focused series of novobiocin derivatives containing a ferrocene unit together with their corresponding organic novobiocin analogues have been synthesized in modest to good yields. These compounds were screened for biological activity against a chloroquine-sens...
作者:Adrienne L. Edkins , Michelle Isaacs ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2016, Vol.26 (15), pp.3810-3812
摘要:Abstract(#br)Encouraging selectivity and low micromolar activity against HeLa cervical carcinoma (IC 50 ⩾ 3.0 μM) and the aggressive MDA-MB-231 triple negative breast carcinoma (IC 50 ⩾ 9.6 μM) cell lines has been exhibited by a number of readily accessible 4-( N -ben...
作者:Adrienne L. Edkins , Selwyn Mapolie
来源:[J].Cancer Letters(IF 4.258), 2015, Vol.357 (1), pp.206-218
摘要:Abstract(#br)Breast cancer is the most common malignancy amongst women worldwide but despite enormous efforts to address this problem, there is still limited success with most of the current therapeutic strategies. The current study describes the anti-cancer activity of a binucle...
作者:Adrienne L. Edkins , Jo-Anne de la Mare ...
来源:[J].Tetrahedron Letters(IF 2.397), 2015, Vol.56 (14), pp.1860-1864
摘要:Abstract(#br)The synthesis of biologically relevant amides and esters is routinely conducted under complex reaction conditions or requires the use of additional catalysts in order to generate sensitive electrophilic species for attack by a nucleophile. Here we present the synthes...
作者:Adrienne L. Edkins , Gillian Borland ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2012, Vol.422 (2), pp.207-212
摘要:Abstract(#br)The human CD23 protein binds to αvβ3 and αvβ5 integrins. The integrins recognize a short tripeptide motif of arg-lys-cys (RKC) in CD23, and peptides containing this motif inhibit the binding of CD23 to B cells and monocytes; neither fibronectin, nor vitronectin,...
作者:Adrienne L. Edkins , Antônio V. Pinto ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2013, Vol.62, pp.98-110
摘要:Abstract(#br)Naphthoquinones have been found to have a wide range of biological activities, including cytotoxicity to cancer cells. The secondary metabolites lapachol, α- and β-lapachone and a series of 25 related synthetic 1,4-naphthoquinones were screened against the oesop...
作者:Adrienne L. Edkins , Carminita L. Frost
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2014, Vol.443 (4), pp.1245-1250
摘要:Abstract(#br)Real-time analysis offers multiple benefits over traditional end point assays. Here, we present a method of monitoring the optimisation of the growth and differentiation of murine 3T3-L1 preadipocytes to adipocytes using the commercially available ACEA xCELLigence Re...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×