全部文献期刊会议图书|学者科研项目
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作者:Adriana Romiti , Rosa Falcone ...
来源:[J].Investigational New Drugs(IF 3.498), 2017, Vol.35 (3), pp.359-374
摘要:In recent years, many anticancer drugs have been tested at metronomic dosages for a variety of tumours. Mechanisms of action attributed to metronomic chemotherapy (MCT) include antiangiogenesis, immunomodulation, direct inhibition of tumour growth, effect on tumour initiating cel...
作者:Adriana Romiti , Rosa Falcone ...
来源:[J].Cancer Letters(IF 4.258), 2017
摘要:Abstract(#br)Pancreatic tumours, the majority of which arise from the exocrine pancreas, have recently shown an increasing incidence in western countries. Over the past few years more and more new selective molecules directed against specific cellular targets have become availabl...
作者:Adriana Romiti , Francesco Leone
来源:[J].European Journal of Cancer(IF 5.061), 2017, Vol.83, pp.106-115
摘要:Abstract(#br)Introduction(#br)The optimal treatment strategy for RAS wild type (WT) mCRC is controversial. Our phase III study investigated the effect of introducing earlier (second-line) or later (third-line) cetuximab in patients progressed after FOLFIRI/bevacizumab first-...
作者:Adriana Romiti , Eliana Rulli ...
来源:[J].Clinical Colorectal Cancer(IF 1.8), 2016
摘要:Abstract(#br)Background(#br)Many studies have disclosed the prognostic effect of microsatellite instability (MSI) and/or loss of mismatch repair proteins in colorectal cancer. Nevertheless, little evidence supports their role in the decision-making of adjuvant therapy for patient...
作者:Adriana Romiti , Mario Occhipinti ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.11 (9)
摘要:5-FU based chemotherapy is the most common first line regimen used for metastatic colorectal cancer (mCRC). Identification of predictive markers of response to chemotherapy is a challenging approach for drug selection. The present study analyzes the predictive role of 5-FU d...
作者:Adriana Romiti , Annalisa Milano ...
来源:[J].Digestive and Liver Disease(IF 3.162), 2016, Vol.48 (12), pp.1503-1505
摘要:Abstract(#br)Background(#br)In recent years, proton pump inhibitors (PPIs) have been investigated at high-dose to modulate tumour microenvironment acidification thus restoring chemotherapeutic sensitivity. Moreover, several clinical data supports the role of cytotoxic drugs at lo...
作者:Adriana Romiti , Rosa Falcone ...
来源:[J].Clinical Colorectal Cancer(IF 1.8), 2016
摘要:Abstract(#br)The acidification of extracellular compartment represents a conceivable mechanism of drug resistance in malignant cells. In addition, it has been reported to drive proliferation and promote invasion and metastasis. Experimental evidence has shown that proton pum...
作者:Adriana Romiti , Silverio Tomao ...
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2003, Vol.86 (1), pp.107-109
摘要:Abstract(#br)To explore the different sequence interactions between reversible non-steroidal (anastrozole, ANZ and letrozole, LTZ) and non-reversible steroidal aromatase inhibitors (formestane, FOR and exemestane, EXE), we evaluated the clinical benefit (CB) in postmenopausa...
作者:Adriana Romiti , Maria Beatrice Musumeci ...
来源:[J].International Journal of Cardiology(IF 5.509), 2013, Vol.167 (6), pp.2421-2429
摘要:Abstract(#br)We aimed to revise the increasingly accruing data about the association between anti-tyrosinkinase, “targeted” cancer drugs and the development of arterial thrombotic events or acute coronary syndromes. Further insights into the involved pathophysiologic mechani...

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