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作者:... T. Voisin , E. Ogier-Denis , A. Couvineau
来源:[J].BBA - Molecular Basis of Disease(IF 4.91), 2018Elsevier
摘要:Abstract(#br)Orexins (orexin-A and orexin-B) are hypothalamic peptides that are produced by the same precursor and are involved in sleep/wake control, which is mediated by two G protein-coupled receptor subtypes, OX1R and OX2R. Ulcerative colitis (UC) is an inflammatory bowe...
作者:... G. Tóth , A. Couvineau , É. Szőke
来源:[J].Neuroscience(IF 3.122), 2015, Vol.308, pp.144-156Elsevier
摘要:Abstract(#br)Pituitary adenylate cyclase-activating polypeptide (PACAP) acts on G protein-coupled receptors: the specific PAC1 and VPAC1/VPAC2 receptors. PACAP6-38 was described as a potent PAC1/VPAC2 antagonist in several models, but recent studies reported its agonistic behavio...
作者:... T. Voisin , A. Couvineau , A. Blais
来源:[J].Nutrition clinique et métabolisme(IF 0.333), 2016, Vol.30 (2), pp.113-113Elsevier
摘要:Introduction et but de l’étude(#br)Les orexines ou hypocrétines 1 et 2, via la stimulation des récepteurs aux orexines 1 (OX1R) et 2 (OX2R), jouent un rôle non seulement dans la régulation des phases d’éveil et de sommeil, de la prise alimentaire, du contrôle du po...
作者:A. Couvineau , P. Gaudin ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 1995, Vol.206 (1), pp.246-252Elsevier
摘要:Abstract(#br)The human VIP receptor belongs to a subfamily of G protein-coupled receptors that includes secretin, glucagon and several other receptors. We have used site-directed mutagenesis to investigate the requirement of highly conserved aspartate 68 (mutant D68G), trypt...
作者:A. Couvineau , E. Ceraudo ...
来源:[J].Neuropeptides(IF 2.067), 2009, Vol.44 (2), pp.127-132Elsevier
摘要:Abstract(#br)The vasoactive intestinal peptide (VIP) is a prominent 28 aminoacid neuropeptide with wide distribution in both central and peripheral nervous systems, where it plays important regulatory role in many physiological processes. VIP has a large spectrum of biologic...
作者:A. Couvineau , J.J. Maoret ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 1995, Vol.211 (3), pp.901-908Elsevier
摘要:Abstract(#br)We have used site-directed mutagenesis to investigate the requirement of cysteine residues in the extracellular domains of the human VIP 1 receptor for binding VIP. Cys 37 , Cys 50 , Cys 63 , Cys 72 , Cys 86 , Cys 105 and Cys 122 (N-terminal extracellular domain), Cy...
作者:A. Couvineau , D. Destefanis ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 1995, Vol.211 (3), pp.935-942Elsevier
摘要:Abstract(#br)We have investigated the effect of a glycosylphosphatidylinositol anchor on the distribution of the soluble lysosomal enzyme cathepsin D. Only 10% of the chimeric protein (CD-GPI) could be detected on the plasma membrane after transfection in CHO cells. Similarly to ...
作者:A. COUVINEAU , J.‐J. LACAPERE
来源:[J].Annals of the New York Academy of Sciences(IF 4.375), 2006, Vol.1070 (1), pp.180-184Wiley
摘要:Abstract: Vasoactive intestinal peptide (VIP) exerts many biological functions through interaction with the VPAC1 receptor, a class II G protein–coupled receptor. Photoaffinity labeling studies associated with receptor mapping and three‐dimensional molecular modeling demonst...

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