全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Elin E. Lilja , David R. Johnson
来源:[J].BMC Evolutionary Biology(IF 3.285), 2017, Vol.17 (1)Springer
摘要:... While diverse solutions to mitigate metabolite toxicity have evolved, less is known about how evolution itself is affected by metabolite toxicity. We hypothesized that the pace of molecular evolution should increase as metabolite toxicity increases. At least two mechanisms co...
作者:Eva Meyerhof , Tanja Sprave , Stefan Ezechiel Welte ...
来源:[J].Trials(IF 2.206), 2017, Vol.18 (1)Springer
摘要:... As a consequence of treatment, the extent of radiation-induced toxicity is a crucial feature with consequences to a patient’s quality of life. In this context this study aims at reducing the extent of radiation-induced side effects and toxicity by assuming a better spa...
作者:Sean A. Hebert , Timothy P. Bohan , Christian L. Erikson ...
来源:[J].BMC Nephrology(IF 1.644), 2017, Vol.18 (1)Springer
摘要:... Drug-induced thrombotic microangiopathy (DI-TMA) is one specific TMA syndrome that occurs following drug exposure via drug-dependent antibodies or direct tissue toxicity. Common examples include calcineurin inhibitors Tacrolimus and Cyclosporine and antineoplastics Gemcitabin...
作者:Jian Zhang , Kai Chen , Yunlong Pang ...
来源:[J].BMC Genomics(IF 4.397), 2017, Vol.18 (1)Springer
摘要:Ferrous iron (Fe) and zinc (Zn) at high concentration in the soil cause heavy metal toxicity and greatly affect rice yield and quality. To improve rice production, understanding the genetic and molecular resistance mechanisms to excess Fe and Zn in rice is essential. Genome-wide ...
作者:Xuerong Zhou , Qian Rong , Min Xu ...
来源:[J].BMC Veterinary Research(IF 1.861), 2017, Vol.13 (1)Springer
摘要:... To provide basis for clinical application, we performed safety pharmacology and subchronic toxicity experiments in specific pathogen-free Sprague-Dawley rats.
作者:Dan Liu , Jian Li , Jing Gao ...
来源:[J].BMC Cancer(IF 3.333), 2017, Vol.17 (1)Springer
摘要:To evaluate a new UGT1A and DPYD polymorphism panel to better predict irinotecan-induced toxicity and the clinical response in Chinese patients with metastatic colorectal cancer (mCRC).
作者:Kevin Matlock , Noah Berlow , Charles Keller ...
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (4)Springer
摘要:... In this article, we consider the individual modeling of drug responses to tumor and normal cells and utilize them to design targeted combination therapies that maximize sensitivity over tumor cells and minimize toxicity over normal cells.
作者:Vienna Ludovini , Cinzia Antognelli , Antonio Rulli ...
来源:[J].BMC Cancer(IF 3.333), 2017, Vol.17 (1)Springer
摘要:We investigated whether GSTT1 (“null” allele ) , GSTM1 (“null”allele ) , GSTP1 (A313G), RFC1 (G80A), MTHFR (C677T), TS (2R/3R) polymorphisms were associated with toxicity and survival in patients with early breast cancer (EBC) treated with adjuvant chemotherapy (CT).
作者:Anchalee Prasansuklab , Krai Meemon , Prasert Sobhon ...
来源:[J].BMC Complementary and Alternative Medicine(IF 2.082), 2017, Vol.17 (1)Springer
摘要:... asper leaf extracts (SA-EE) against toxicity of glutamate-mediated oxidative stress, a crucial factor contributing to the neuronal loss in age-associated neurodegenerative diseases and the underlying mechanism as well as to evaluate its longevity effect.
作者:Saiqa Ishtiaq , Maida Akram , Sairah Hafeez Kamran ...
来源:[J].BMC Complementary and Alternative Medicine(IF 2.082), 2017, Vol.17 (1)Springer
摘要:Herbology is the prevailing system among the nationally-accepted alternative or complementary systems of medicine. The system is due to its general and patient-oriented methodology, is widely used in the general population exposing them to the risk of the side effects of the herb...

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