全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Tetsuya Fujiwara , Takeshi Tsutsumi , Kohei Nakata ...
来源:[J].Molecules(IF 2.428), 2017, Vol.22 (1)DOAJ
摘要:Expedient asymmetric total syntheses of both (R)-podoblastin-S and (R)-lachnelluloic acid, representative of natural 3-acyl-5,6-dihydro-2H-pyran-2-ones, were performed. Compared with the reported total synthesis of (R)-podoblastin-S (14 steps, overall 5% yield), the present s...
作者:Xiaoji Wang , Junmin Feng , Zhengshuang Xu ...
来源:[J].Marine Drugs(IF 3.978), 2017, Vol.15 (3)DOAJ
摘要:... Both R‐ and S‐2‐hydroxy‐4‐(4‐hydroxy‐phenyl) butanoic acid (Hhpba) were prepared and incorporated into the total synthesis of nostosin B, respectively. Careful comparison of the NMR spectra and optical rotation data of synthetic nostosin B (1a and 1b) with ...
作者:Peter H. Seeberger , Claney L. Pereira , Subramanian Govindan
来源:[J].Beilstein Journal of Organic Chemistry(IF 2.801), 2017, Vol.13 (1), pp.164-173DOAJ
摘要:... A better immunological understanding of the epitopes that protect from bacterial infection requires defined oligosaccharides obtained by total synthesis. The key to the synthesis of the S. pneumoniae serotype 12F CPS hexasaccharide repeating unit that is not contained in c...
作者:Lili Yeung , Lisa I. Pilkington , Melissa M. Cadelis ...
来源:[J].Beilstein Journal of Organic Chemistry(IF 2.801), 2015, Vol.11 (1), pp.1991-1996DOAJ
摘要:The first total synthesis of the unusual aromatic sesquiterpene panicein A2 is reported and the structure of the natural product has been confirmed. When tested by the NCI against a range of human cancer cell lines, it was found that panicein A2 exhibit...
作者:Ruina Wang , Guoyue Liu , Mingyan Yang ...
来源:[J].Molecules(IF 2.428), 2016, Vol.21 (5)DOAJ
摘要:Total synthesis of naturally occurring spirobisnaphthalene palmarumycin CP17 and its methoxy analogues was first achieved through Friedel-Crafts acylation, Wolff-Kishner reduction, intramolecular cyclization, ketalization, benzylic oxidation, and demethylation using the inex...
作者:Zheng Yang , Nianyu Huang , Bang Xu ...
来源:[J].Molecules(IF 2.428), 2016, Vol.21 (3)DOAJ
摘要:... Their structures were elucidated mainly by spectroscopic analysis, total synthesis and X-ray crystallographic analysis. Biological evaluations indicated that compound 1, 3a and 3 exhibit potent cytotoxicity against different cancer cell lines through inhibiting the phosphoryl...
作者:Masashi Yokoya , Keiichiro Kobayashi , Mitsuhiro Sato ...
来源:[J].Marine Drugs(IF 3.978), 2015, Vol.13 (8), pp.4915-4933DOAJ
摘要:The first total synthesis of (±)-renieramycin I, which was isolated from the Indian bright blue sponge Haliclona cribricutis, is described. The key step is the selenium oxide oxidation of pentacyclic bis-p-quinone derivative (3) stereo- and regioselectively. We also report a...
作者:Rodrigo V. Pirovani , Gilmar A. Brito , Rosimeire C. Barcelos ...
来源:[J].Marine Drugs(IF 3.978), 2015, Vol.13 (6), pp.3309-3324DOAJ
摘要:... Here the first total synthesis of (+)-lyngbyabellin M is described based on the coupling of three key intermediates: two chiral thiazole moieties and an anti hydroxycarboxylic acid prepared stereoselectively via a boron enolate mediated aldol reaction directed by Masamu...
作者:Li Wang , Ping-Ping Shou , Si-Ping Wei ...
来源:[J].Molecules(IF 2.428), 2016, Vol.21 (1)DOAJ
摘要:An enantioselective total synthesis of chiral falcarindiol analogues from buta-1,3-diyn-1-yltriisopropylsilane is reported. The key step in this synthesis is BINOL-promoted asymmetric diacetylene addition to aldehydes. The two chiral centers of the falcarindiol analogues can be p...
作者:Barbara C. Potts , Kin S. Lam
来源:[J].Marine Drugs(IF 3.978), 2010, Vol.8 (4), pp.835DOAJ
摘要:... Methods to generate this class of compounds include fermentation and natural products chemistry, precursor-directed biosynthesis, mutasynthesis, semi-synthesis, and total synthesis. The end products range from biochemical tools for probing mechanism of action to clinical tria...

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