全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Zheng Wang , Zhimin Chang , Mengmeng Lu ...
来源:[J].Biomaterials(IF 7.604), 2018, Vol.154, pp.147-157Elsevier
摘要:Abstract(#br)Magnetic nanoparticles (NPs) have emerged as a promising tool for suicide gene therapy. However, the separate delivery of the suicide gene and prodrug in current systems limits their clinical translation. Therefore, improving magnetically mediated suicide gene therapy...
作者:Jehad Zweiri , Stephen E. Christmas
来源:[J].Cancer Cell International(IF 2.093), 2017, Vol.17 (1)Springer
摘要:Cellular based therapeutic approaches for cancer rely on careful consideration of finding the optimal cell to execute the cellular goal of cancer treatment. Cell lines and primary cell cultures have been used in some studies to compare the in vitro and in vivo efficacy of autolog...
作者:Bulbul Tirkey , Bharat Bhushan , S. Uday Kumar ...
来源:[J].Materials Science & Engineering C(IF 2.404), 2017, Vol.73, pp.507-515Elsevier
摘要:... Among such alternative approaches, CD::UPRT (cytosine deaminase uracil phosphoribosyl transferase) suicide gene therapy has tremendous potential due to its high efficacy. Prodrug 5-Fluorocytosine (5-FC) used in combination with CD::UPRT suicide gene suffers from limited solub...
作者:Chen Daozhen , Tang Qiusha
来源:[J].BMC Cancer(IF 3.333), 2010, Vol.10 (1), pp.609DOAJ
摘要:Abstract Background To evaluate the killing effect of HSV-TK/GCV suicide gene therapy system combined with 60Co radiotherapy on human cervical cancer Hela cell line in vitro and in vivo , and to explore the radiosensitization by HSV-TK/GCV system. Methods HSV-TK/GCV suicide gene therapy...
作者:Young-Wook Won , Kyung-Min Kim , Sung Su An ...
来源:[J].Biomaterials(IF 7.604), 2011, Vol.32 (36), pp.9766-9775Elsevier
摘要:Abstract(#br)Suicide gene therapy based on a combination of herpes simplex virus-thymidine kinase (HSV-tk) and ganciclovir (GCV) has obstacles to achieving a success in clinical use for the treatment of cancer due to inadequate thymidine kinase (TK) expression. The primary concer...
作者:Man Li , Shoujia Sun , Sean Dangelmajer ...
来源:[J].Stem Cell Research & Therapy(IF 3.652), 2019, Vol.10 (1), pp.1-15DOAJ
摘要:Human mesenchymal stem cell (MSC)-based tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene delivery is regarded as an effective treatment for glioblastoma (GBM). However, adverse-free target site homing of the delivery vehicles to the tumor microsatellite nests ...
作者:Yuchen Sun , Josefina Piñón Hofbauer , Manami Harada ...
来源:[J].Cancer Letters(IF 4.258), 2018Elsevier
摘要:... Given its excellent cancer-specific expression profile, we hypothesized that Ct-OATP1B3 could represent a promising target for cancer-specific expression of the suicide gene, herpes simplex virus 1 thymidine kinase (HSV- tk ), via a spliceosome-mediated RNA trans -splicing (S...
作者:Weiwei Hu , Weiguo Liu
来源:[J].In Vitro Cellular & Developmental Biology - Animal(IF 1.289), 2010, Vol.46 (6), pp.497-501Springer
摘要:... The herpes simplex virus thymidine kinase/ganciclovir suicide gene therapy system is one of the best-characterized strategies for malignant tumors including glioblastoma. Since this system involves a small-molecule drug ganciclovir, we wonder if glioblastoma side population...
作者:Sónia Duarte , Georges Carle , Henrique Faneca ...
来源:[J].Cancer Letters(IF 4.258), 2012, Vol.324 (2), pp.160-170Elsevier
摘要:Abstract(#br)Suicide gene therapy is based on the introduction into tumor cells of a viral or a bacterial gene, which allows the conversion of a non-toxic compound into a lethal drug. Although suicide gene therapy has been successfully used in a large number of in vitro and in vi...
作者:Tang Wei , He Yunfeng , Zhou Shengcai ...
来源:[J].Journal of Experimental & Clinical Cancer Research(IF 3.066), 2009, Vol.28 (1), pp.155DOAJ
摘要:... In order To search for novel targeted and efficacious treatment, we sought to investigate anti-tumor activity of BI-TK suicide gene therapy system in a rat model of bladder tumors. We first constructed and tested an anaerobic Bifidobacterium infantis-mediated thymidine kinase...

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