全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Lucy Dorey , Ludovic Pelligand , Peter Lees
来源:[J].BMC Veterinary Research(IF 1.861), 2017, Vol.13 (1)Springer
摘要:... In recent years there have been major developments in dosage schedule design, based on integration and modelling of pharmacokinetic (PK) and pharmacodynamic (PD) data, with the objective of optimising efficacy and minimising the emergence of resistance. From in vitro time-kil...
作者:Raquel Díez , Juan José García , María José Diez ...
来源:[J].BMC Complementary and Alternative Medicine(IF 2.082), 2017, Vol.17 (1)Springer
摘要:Metformin is an oral hypoglycemic agent frequently used in patients with type 2 diabetes. In this study, we have investigated the influence of the dietary fiber Plantago ovata husk on the pharmacokinetics of this drug when included in the diet, as well as when administered at the...
作者:Dennison TJ , Smith JC , Badhan RK ...
来源:[J].Drug Design, Development and Therapy(IF 3.486), 2017, Vol.Volume11, pp.811-826DOAJ
摘要:... This work follows the development and characterization of single and FDC ODTs containing amlodipine and atorvastatin, followed by bioequivalence comparison between these single and FDC formulations, using in vitro dissolution and Caco-2 apparent permeability (Papp) and in silico physiologically based pharmacokinetic...
作者:Ahmed TA
来源:[J].International Journal of Nanomedicine(IF 3.463), 2016, Vol.2016 (Issue 1), pp.515-527DOAJ
摘要:... Freeze-dried NPs formulation was subsequently loaded into hard gelatin capsules that were examined for in vitro dissolution and pharmacokinetic behavior. Results revealed that in most of the studied variables, some of the quadratic and interaction effects had a significant...
作者:Lieven Van Meulebroek , Nathalie De Clercq , Julie Vanden Bussche ...
来源:[J].BMC Veterinary Research(IF 1.861), 2017, Vol.13 (1)Springer
摘要:... In this study, the validity of these strategies was verified by investigating the plasma pharmacokinetic and urinary excretion profiles of relevant glucocorticoids in bovines, subjected to exogenous prednisolone treatment or tetracosactide hexaacetate administration to indu...
作者:Shun Asami , Daisuke Kiga , Akihiko Konagaya
来源:[J].BMC Systems Biology(IF 2.982), 2017, Vol.11 (7)Springer
摘要:... As a useful tool to predict individual phenomena and correlations among drug characteristics and individual varieties, recently, whole-body physiologically based pharmacokinetic (WB- PBPK) models are getting more attention. WB-PBPK models generally have a lot of drug-related ...
作者:Mahesh V. Attimarad , Anroop B. Nair , Bandar E. Aldhubaib
来源:[J].Journal of the Iranian Chemical Society(IF 1.467), 2015, Vol.12 (9), pp.1629-1636Springer
摘要:... Subsequently, the method was applied to determine the pharmacokinetic parameters such as T max, C max, AUC0–t, T 1/2, and Kel for both the drugs in plasma. The developed LC–MS method has been successfully used for the simulta...
作者:Masayo Oishi , Yuma Takano , Yutaka Torita ...
来源:[J].Drug Metabolism and Pharmacokinetics(IF 2.071), 2018, Vol.33 (1), pp.90-95Elsevier
摘要:... Utilizing the available pharmacokinetic characteristics of fesoterodine and 5-HMT, we estimated in vivo Ki of ketoconazole on P-gp at kidney based on DDI study data using physiologically-based pharmacokinetic approach. The estimated in vivo Ki of ketoconazole for hepatic C...
作者:Bungorn Sripanidkulchai , Catheleeya Mekjaruskul , Rosawan Areemit ...
来源:[J].Nutrients(IF 2.072), 2019, Vol.11 (5)DOAJ
摘要:... This study focused on the oral glucose tolerance test and pharmacokinetic study in healthy volunteers administered with KP extract (90 and 180 mg/day, placebo). The oral glucose tolerance tests were performed at baselines and 28-days of administration. The pharmacokinetics...
作者:Carlander U , Li D , Jolliet O ...
来源:[J].International Journal of Nanomedicine(IF 3.463), 2016, Vol.2016 (Issue 1), pp.625-640DOAJ
摘要:... Experience with industrial chemicals and pharmaceutical drugs reveals that biokinetics can be described and predicted accurately by physiologically-based pharmacokinetic (PBPK) modeling. The nano PBPK models developed to date all concern a single type of NP. Our aim here was ...

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