全部文献期刊会议图书|学者科研项目
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作者:Carlos César Patiño-Morales , Ernesto Soto-Reyes , Elena Arechaga-Ocampo ...
来源:[J].Redox Biology, 2020, Vol.28
摘要:Abstract(#br)Curcumin is a natural phytochemical with potent anti-neoplastic properties including modulation of p53. Targeting p53 activity has been suggested as an important strategy in cancer therapy. The purpose of this study was to describe a mechanism by which curcumin resto...
作者:Jiale Wu , Ying Liang , Yun Tan ...
来源:[J].Cellular Signalling(IF 4.304), 2020, Vol.67
摘要:Abstract(#br)Loss of p53's tumor-suppressive function, either via TP53 mutation or hyperactive p53 inhibitory proteins, is one of the most frequent events in the development of human cancer. Here, we describe a strategy of pharmacologically inhibiting iASPP, a negative regulato...
作者:Yu-Ling Wang , Wei Wu , Yong-Nan Su ...
来源:[J].Phytomedicine(IF 2.972), 2020, Vol.68
摘要:Abstract(#br)Background(#br)P53 is the most frequently mutated gene in most tumour types, and the mutant p53 protein accumulates at high levels in tumours to promote tumour development and progression. Thus, targeting mutant p53 for degradation is one of the therapeutic strategie...
作者:Małgorzata Krześniak , Artur Zajkowicz , Agnieszka Gdowicz-Kłosok ...
来源:[J].Cellular Signalling(IF 4.304), 2020, Vol.69
摘要:Abstract(#br)Actinomycin D and nutlin-3a (A + N) activate p53, partly through induction of phosphorylation on Ser392. The death of A549 cells induced by A + N morphologically resembles inflammation-inducing pyroptosis - cell destruction triggered by activated caspase-1. The treat...
作者:Caroline M. Molle , Guillaume Arguin , Charlotte Jemfer ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2020, Vol.524 (4), pp.798-802
摘要:Abstract(#br)Inflammatory bowel disease (IBD) is a risk factor for the development of colorectal cancer (CRC) for which mutation to p53 is an early event leading to dysplasia. Interestingly, P2RY6 mRNA increases in both pathologies. In this study, we investigated if p53 and p53...
作者:Jane K. Nguyen , Christopher G. Przybycin , Jesse K. McKenney ...
来源:[J].Human Pathology(IF 2.843), 2020, Vol.98, pp.81-88
摘要:... Given frequent increased proliferation rates in florid reactive urothelial atypia and limited studies on the interpretation of p53 stains in the urothelium (following current standard guidelines for correlation with P53 mutation status), we sought to further study the discr...
作者:Tianhe Zhao , Donglei Sun , Manyu Zhao ...
来源:[J].Environmental Pollution(IF 3.73), 2020, Vol.259
摘要:... However, whether m 6 A can regulate p53, a leading antitumor protein remains poorly understood. In this study, we explored the regulatory role of m 6 A on p53 activation using an arsenite-transformed keratinocyte model, the HaCaT-T cell line. We created the cell line by ex...
作者:Yating Wang , Genji Bai , Xi Zhang ...
来源:[J].Magnetic Resonance Imaging(IF 2.06), 2020, Vol.68, pp.183-189
摘要:Abstract(#br)Purposes(#br)To investigate the relationship between apparent diffusion coefficient (ADC) value and p53 and ki-67 expression in esophageal squamous cell carcinoma (ESCC) patients.(#br)Materials and methods(#br)Clinical, pathologic and MRI findings of 55 ESCC pati...
作者:Haroon Khan , Marcella Reale , Hammad Ullah ...
来源:[J].Biotechnology Advances(IF 9.599), 2020, Vol.38
摘要:Abstract(#br)The anticancer effects of polyphenols are ascribed to several signaling pathways including the tumor suppressor gene tumor protein 53 (p53). Expression of endogenous p53 is silent in various types of cancers. A number of polyphenols from a wide variety of dietary sou...
作者:Siddharth De , Callum Campbell , Ashok R. Venkitaraman ...
来源:[J].Cell Reports, 2020, Vol.30 (7), pp.2083-2093.e5
摘要:Summary(#br)Cell-autonomous changes in p53 expression govern the duration and outcome of cell-cycle arrest at the G2 checkpoint for DNA damage. Here, we report that mitogen-activated protein kinase (MAPK) signaling integrates extracellular cues with p53 dynamics to determine cell...

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