全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Xiaohong Lu , Yuanjie Yu , Shiyun Tan
来源:[J].BMC Gastroenterology(IF 2.11), 2017, Vol.17 (1)Springer
摘要:Tumor suppressor gene p53 expression has been reported in patients with ulcerative colitis (UC). However, the correlation between p53 expression and UC remains controversial. The aim of this meta-analysis was to investigate the association between p53 expression and different pat...
作者:Qijiong Li , Xiaofeng Liu , Kemin Jin ...
来源:[J].BMC Cancer(IF 3.333), 2017, Vol.17 (1)Springer
摘要:... Previous study showed that NAT10 acetylates the tumor suppressor p53 and regulates p53 activation. As Tp53 gene is frequently mutated in hepatocellular carcinoma (HCC) and associates with the occurrence and development of HCC, the relationship between NAT10 and HCC was invest...
作者:Kengo Shimazu , Yuji Tada , Takao Morinaga ...
来源:[J].BMC Cancer(IF 3.333), 2017, Vol.17 (1)Springer
摘要:Mesothelioma is resistant to conventional treatments and is often defective in p53 pathways. We then examined anti-tumor effects of metformin, an agent for type 2 diabetes, and combinatory effects of metformin and nutlin-3a, an inhibitor for ubiquitin-mediated p53 degradation, on...
作者:Shaowei Qiu , Shuang Liu , Tengteng Yu ...
来源:[J].BMC Cancer(IF 3.333), 2017, Vol.17 (1)Springer
摘要:As the important suppressor of P53, iASPP is found to be overexpressed in leukemia, and functions as oncogene that inhibited apoptosis of leukemia cells. Sertad1 is identified as one of the proteins that can bind with iASPP in our previous study by two-hybrid screen.
作者:Elham Parandavar , Razieh Yazdanparast
来源:[J].Cell & Bioscience(IF 3), 2017, Vol.7 (1)Springer
摘要:... Aside from its transcriptional regulation, other mechanisms, such as post translational modifications and protein–protein interactions, the interaction between HIF-1α and p53 has attracted more attention mainly due to simultaneous enhancement in the protein levels of t...
作者:Jinjin Xu , Jian Jiao , Wei Xu ...
来源:[J].Science China Life Sciences(IF 2.024), 2017, Vol.60 (9), pp.1019-1029Springer
摘要:Abstract(#br)The tumor suppressor p53 protein is either lost or mutated in about half of all human cancers. Loss of p53 function is well known to influence cell spreading, migration and invasion. While expression of mutant p53 is not equivalent to p53 loss, mutant p53 can acquire...
作者:Suguru Yamauchi , Boya Zhong , Kiyoko Kawamura ...
来源:[J].BMC Cancer(IF 3.333), 2017, Vol.17 (1)Springer
摘要:Replication-competent adenoviruses (Ad) produced cytotoxic effects on infected tumors and have been examined for the clinical applicability. A biomarkers to predict the cytotoxicity is valuable in a clinical setting.
作者:Akiko Okuda , Suguru Kurokawa , Masanori Takehashi ...
来源:[J].BMC Neuroscience(IF 3), 2017, Vol.18 (1)Springer
摘要:Poly(ADP-ribose) polymerase 1 (PARP-1), which catalyzes poly(ADP-ribosyl)ation of proteins by using NAD+ as a substrate, plays a key role in several nuclear events, including DNA repair, replication, and transcription. Recently, PARP-1 was reported to participate in th...
作者:Luo X , Deng C , Liu F ...
来源:[J].OncoTargets and Therapy(IF 2.073), 2019, Vol.Volume 12, pp.4269-4279DOAJ
摘要:...After silencing hnRNPL, the expression of hnRNPL, p53 and Bcl-2 were detected by RT-qPCR and Western blot in WT cell line. The regulatory effects of hnRNPLon proliferative and apoptotic potentials of WT cells were evaluated by MTT and flow cytometry, respectively. RNA-bind...
作者:Swati Singla , Gaurav Singla , Sufian Zaheer ...
来源:[J].Journal of Cancer Research and Therapeutics(IF 0.761), 2018, Vol.14 (2), pp.388-393DOAJ
摘要:... The most frequently observed genetic aberrations in these lesions are of mutations in p53, c-erbB2, and epidermal growth factor receptor (EGFR). No specific tumor markers have been identified consistently in oral leukoplakias and the available studies show wide variations i...

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