全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Na Young Jang , Dan Hyo Kim , Bong Jun Cho ...
来源:[J].BMC Cancer(IF 3.333), 2015, Vol.15 (1)Springer
摘要:... Therefore, we assessed the radiosensitizing effect, and the underlying mechanism of combination treatment with PARP inhibitor olaparib and PI3K inhibitor PI-103 in BRCA-proficient TNBC cells.(#br) Methods(#br)MDA-MB-435S cells were divided into four treatment groups, irradi...
作者:De Felice F , Tombolini V , Marampon F ...
来源:[J].Drug Design, Development and Therapy(IF 3.486), 2017, Vol.Volume11, pp.547-552DOAJ
摘要:... Olaparib is an oral PARP inhibitor that blocks DNA repair pathway and coupled with BRCA mutated-disease results in tumor cell death. In phase II clinical trials, including patients with advanced castration-resistant PC, olaparib seems to be efficacious and well tolerated. ...
作者:Ignacio Campillo-Marcos , Pedro A. Lazo
来源:[J].Journal of Experimental & Clinical Cancer Research(IF 3.066), 2019, Vol.38 (1), pp.1-16DOAJ
摘要:... Methods Tumor cell lines with different genetic backgrounds were treated with olaparib to determine their effect on the activation of DNA repair pathways induced by ionizing radiation. The effect of combining olaparib with depletion of the chromatin kinase VRK1 was studie...
作者:Mohamed A Ghonim , Kusma Pyakurel , Salome V Ibba ...
来源:[J].Journal of Translational Medicine(IF 3.459), 2015, Vol.13 (1)Springer
摘要:... Olaparib, a PARP inhibitor, was recently introduced in clinical trials against cancer. The objective of the present study was to examine the efficacy of olaparib in blocking established allergic airway inflammation and hyperresponsiveness similar to those observed in hum...
作者:Hye Jeong Park , Jun Sang Bae , Kyoung Min Kim ...
来源:[J].Journal of Experimental & Clinical Cancer Research(IF 3.066), 2018, Vol.37 (1), pp.1-15DOAJ
摘要:... Methods We evaluated the expression of DNA damage response molecules in 35 human osteosarcomas and investigated the effects of co-treatment of the PARP inhibitor, olaparib, and doxorubicin in osteosarcoma cells. Results The expression patterns of PARP1, γH2AX, BRCA1, and...
作者:Viviane C. Ruiz-Schutz , Larissa M. Gomes , Rodrigo C. Mariano ...
来源:[J].Critical Reviews in Oncology / Hematology(IF 4.637), 2019, Vol.141, pp.163-173Elsevier
摘要:... Olaparib is FDA-approved for advanced breast cancer and advanced ovarian cancer patients. Fatigue and anemia are among the most common cancer and treatment-related symptoms. Therefore, we conducted a meta-analysis of randomized controlled trials (RCT) to characterize the i...
作者:Luc Dirix , Helen Swaisland , Henk M.W. Verheul ...
来源:[J].Clinical Therapeutics(IF 2.23), 2016, Vol.38 (10), pp.2286-2299Elsevier
摘要:Abstract(#br)Purpose(#br)The metabolism of olaparib, a potent inhibitor of poly(ADP-ribose) polymerase (PARP) with demonstrated efficacy in patients with BRCA -mutated ovarian cancer, is mediated by cytochrome P450 (CYP) enzymes (predominantly CYP3A4/5). We assessed the poten...
作者:Xu K , Chen Z , Cui Y ...
来源:[J].OncoTargets and Therapy(IF 2.073), 2015, Vol.2015 (default), pp.3047-3054DOAJ
摘要:... Methods: A cell counting kit-8 assay was used to determine the sensitivity of CRC cells to olaparib and/or oxaliplatin. The gene and protein expressions of PARP1 and the gamma histone variant H2AX (ΓH2AX) were measured by real-time quantitative polymerase chain reaction and...
作者:Alecu I , Milenkova T , Turner SR
来源:[J].Drug Design, Development and Therapy(IF 3.486), 2018, Vol.Volume 12, pp.347-348DOAJ
摘要:... The authors concluded that olaparib resulted in a higher incidence of severe (common terminology criteria for adverse events [CTCAE] grade $3) neutropenia when compared with niraparib and veliparib; however, these conclusions are based on inappropriate and incomplete comparis...
作者:Ymera Pignochino , Federica Capozzi , Lorenzo D’Ambrosio ...
来源:[J].Molecular Cancer(IF 5.134), 2017, Vol.16 (1)Springer
摘要:Enhancing the antitumor activity of the DNA-damaging drugs is an attractive strategy to improve current treatment options. Trabectedin is an isoquinoline alkylating agent with a peculiar mechanism of action. It binds to minor groove of DNA inducing single- and double-strand-break...

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