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作者:Rania M. Salama , Azza H. Abd Elwahab , Mona M. Abd-Elgalil ...
来源:[J].Toxicology(IF 4.017), 2020, Vol.437
摘要:... In addition to the cardiovascular benefits of LCZ696 (sacubitril/valsartan (VAL)), neprilysin inhibition was shown to mediate Ca 2+ sequestration inside the ER. Furthermore, long noncoding RNA taurine-upregulated gene 1 (lncRNA TUG1) was shown to ameliorate apoptosis in vario...
作者:H M Stephen , R J Khoury , P R Majmudar ...
来源:[J].Oncogenesis, 2016, Vol.5 (3), pp.e207-e207
摘要:... Neprilysin, a cell-surface enzyme that cleaves and inactivates a number of substrates including endothelin-1 (ET1), has been implicated in breast cancer, but whether neprilysin promotes or inhibits breast cancer cell progression and metastasis is unclear. Here, we asked ...
作者:Sadayoshi Ito , Minoru Satoh , Yuko Tamaki ...
来源:[J].Hypertension Research(IF 2.791), 2015, Vol.38 (Suppl 4), pp.269-275
摘要:Abstract(#br)This 8-week, multi-center, open-label study assessed the safety and efficacy of LCZ696, a first-in-class angiotensin receptor neprilysin inhibitor, in Japanese patients with hypertension and renal dysfunction. Patients ( n =32) with mean sitting systolic blood press...
作者:Stephen Moss , Vasanta Subramanian , K. Ravi Acharya
来源:[J].Journal of Structural Biology(IF 3.361), 2018
摘要:Abstract(#br)Neprilysin is a transmembrane M13 zinc metalloprotease responsible for the degradation of several biologically active peptides including insulin, enkephalin, substance P, bradykinin, endothelin-1, neurotensin and amyloid-β. The protein has received attention for it...
作者:Lodi C.W. Roksnoer , Estrellita Uijl , René de Vries ...
来源:[J].European Journal of Pharmacology(IF 2.592), 2018, Vol.824, pp.128-132
摘要:... Hence, interference with other systems is currently being investigated, like potentiation of natriuretic peptides with neprilysin inhibitors. However, the neprilysin inhibitor thiorphan was recently found to increase endothelin-1 when administered to TGR(mREN2)27 (Ren2) rats...
作者:R. Stinkens , B. W. van der Kolk , J. Jordan ...
来源:[J].Scientific Reports(IF 2.927), 2018, Vol.8 (1), pp.875-892
摘要:... We have recently demonstrated that sacubitril/valsartan (LCZ696), a first-in-class angiotensin receptor neprilysin inhibitor, which blocks the angiotensin II type-1 receptor and augments natriuretic peptide levels, improved peripheral insulin sensitivity in obese hypertensi...
作者:Daniel Pfau , Stephanie L. Thorn , Jiasheng Zhang ...
来源:[J].Scientific Reports(IF 2.927), 2019, Vol.9 (1), pp.594-605
摘要:Abstract(#br)Angiotensin receptor blocker-neprilysin inhibitor (ARNi) therapy improves the prognosis of heart failure patients. However, the mechanisms remain unclear. This study investigated the biological effects of ARNi with neprilysin inhibitor sacubitril and angiotensin rece...
作者:Noemi Pavo , Henrike Arfsten , Anna Cho ...
来源:[J].Scientific Reports(IF 2.927), 2019, Vol.9 (1), pp.993-1004
摘要:Abstract(#br)The transmembrane zink-metalloendopeptidase neprilysin (NEP) is implicated in cardiovascular disease but also tumor biology. The aim of the study was to investigate the relationship of circulating NEP (cNEP) levels with established cardiovascular biomarkers and it...
作者:Rachel M. Genova , Kacie J. Meyer , Michael G. Anderson ...
来源:[J].Scientific Reports(IF 2.927), 2018, Vol.8 (1), pp.7-23
摘要:Abstract(#br)Neprilysin (NEP), an ectoenzyme that modulates inflammation by degrading neuropeptides, was recently identified in the human corneal epithelium. The cornea expresses many NEP substrates, but the function of NEP in homeostatic maintenance and wound healing of the co...

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