全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Zhao JH , Zhang QB , Liu B ...
来源:[J].International Journal of Nanomedicine(IF 3.463), 2017, Vol.Volume 12, pp.4763-4772DOAJ
摘要:... To reduce the toxicity of PD, OVA, and adjuvant were loaded together into liposomes before being incorporated into a dissolving microneedle array.Methods: OVA- and PD-loaded liposomes (OVA-PD-Lipos) were prepared using the film dispersion method. Their uptake behavior, toxi...
作者:Bahareh Abtahi-Naeini , Farahnaz Fatemi Naeini , Neda Adibi ...
来源:[J].Journal of Research in Medical Sciences(IF 0.684), 2015, Vol.20 (7), pp.631-635DOAJ
摘要:... The aim of this study was to investigate the QOL in patients with PAH before and after treatment with fractionated microneedle radiofrequency (FMR). Materials and Methods: We evaluated 25 patients with severe PAH. Each patient had three sessions of FMR treatment using a ...
作者:Renxin Wang , Wei Wang , Zhihong Li
来源:[J].Sensors(IF 1.953), 2016, Vol.16 (10)DOAJ
摘要:Silicon microneedle arrays (MNAs) have been widely studied due to their potential in various transdermal applications. However, discrete MNAs, as a preferred choice to fabricate flexible penetrating devices that could adapt curved and elastic tissue, are rarely reported. Furtherm...
作者:Jaya Arya , Sebastien Henry , Haripriya Kalluri ...
来源:[J].Biomaterials(IF 7.604), 2017, Vol.128, pp.1-7Elsevier
摘要:Abstract(#br)To support translation of microneedle patches from pre-clinical development into clinical trials, this study examined the effect of microneedle patch application on local skin reactions, reliability of use and acceptability to patients. Placebo patches containing dis...
作者:Chandrateja Uppuluri , Ashraf Sultana Shaik , Tao Han ...
来源:[J].AAPS PharmSciTech(IF 1.584), 2017, Vol.18 (5), pp.1495-1506Springer
摘要:The present study was aimed to investigate the effect of salient microneedle (MN) geometry parameters like length, density, shape and type on transdermal permeation of rizatriptan (RIZ). Studies were carried out using two types of MN devices viz. AdminPatch® arrays (ADM) (0.6...
作者:KangJu Lee , Hyun Beom Song , Wonwoo Cho ...
来源:[J].Acta Biomaterialia(IF 5.093), 2018Elsevier
摘要:... Microneedle (MN) technology can deliver therapeutic molecules to the eye in a minimally invasive manner. However, the current ocular MN technology is limited to either short-term corneal drug delivery or retinal drug delivery by suprachoroidal injection. For long-term and min...
作者:Minjae Kim , Taewan Kim , Dong Sung Kim ...
来源:[J].Sensors(IF 1.953), 2015, Vol.15 (7), pp.16265-16280DOAJ
摘要:... In this paper, we propose a flexible band-integrated, curved microneedle array electrode for robust long-term measurements, high selectivity, and easy applicability. Signal quality, in terms of long-term usability and sensitivity to perspiration, was investigated. Its motion-...
作者:Youngsam Yoon , Gil S. Lee , Koangki Yoo ...
来源:[J].Sensors(IF 1.953), 2013, Vol.13 (12), pp.16672-16681DOAJ
摘要:We report fabrication of a microneedle-based three-electrode integrated electrochemical sensor and in-vitro characterization of this sensor for glucose sensing applications. A piece of silicon was sequentially dry and wet etched to form a 15 × 15 array of tall (approximately 38...
作者:Grace Cole , Ahlam A. Ali , Emma McErlean ...
来源:[J].Acta Biomaterialia(IF 5.093), 2019, Vol.96, pp.480-490Elsevier
摘要:... This study was designed to evaluate the efficacy of a two-tier delivery system incorporating cationic RALA/pDNA nanoparticles (NPs) into a dissolvable microneedle (MN) patch for the purposes of DNA vaccination against prostate cancer. Application of NP-loaded MN patches s...
作者:Peipei Yang , Chao Lu , Wanbing Qin ...
来源:[J].Acta Biomaterialia(IF 5.093), 2020, Vol.104, pp.147-157Elsevier
摘要:... Here, a highly drug-concentrated hybrid core-shell microneedle (CSMN) system for co-delivery of checkpoint inhibitors was developed. Based on the specific drug-matrix interaction, the system concentrated aPD-L1 in the tips of microneedles through electrostatic interactions, a...

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