全部文献期刊会议图书|学者科研项目
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作者:Bettina Sehnert , Harald Burkhardt , Stephanie Finzel ...
来源:[J].Clinical Immunology(IF 3.771), 2018, Vol.186, pp.14-20
摘要:Abstract(#br)Small molecules interfering with intracellular signalling pathways are used in the treatment of multiple diseases including RA. However, small molecules usually affect signalling in most cell types, not only in those which need to be targeted. This general inhibition...
作者:Sahabul Alam , Debashis De
来源:[J].Information Fusion(IF 2.262), 2019, Vol.49, pp.100-119
摘要:... This article proposes a wireless sensor network based smog sensing model for a city by mimicking of biological intracellular signalling. The proposed model is designed and simulated using QualNet 7.1. The several performance features like energy consumption, signals transmis...
作者:Marc Sturrock , Alan J. Terry , Dimitris P. Xirodimas ...
来源:[J].Journal of Theoretical Biology(IF 2.351), 2010, Vol.273 (1), pp.15-31
摘要:Abstract(#br)The correct localisation of transcription factors is vitally important for the proper functioning of many intracellular signalling pathways. Experimental data has shown that many pathways exhibit oscillations in concentrations of the substances involved, both tempo...
作者:Monia Monti , Keren S. Borensztajn , Mirko Pinotti ...
来源:[J].Thrombosis Research(IF 3.133), 2008, Vol.123 (6), pp.914-918
摘要:Abstract(#br)Introduction(#br)Factor X (FX) is a serine-protease playing a crucial role in the blood coagulation pathway and triggering intracellular signalling in a variety of cells via protease-activated receptors (PARs). By exploiting naturally occurring variants (V342A a...
作者:M.R. Young , S.M. Fleetwood-Walker , R. Mitchell ...
来源:[J].Neuropharmacology(IF 4.114), 1995, Vol.34 (8), pp.1033-1041
摘要:... Effects of ionophoresis of the mGluR antagonists ( R , S )-CHPG and l -AP3 and a range of selective inhibitors of intracellular signalling pathways were examined on evoked responses here. The results suggest that protein kinase C, phospholipase A 2 and perhaps Ca 2+ /calmodul...
作者:Pan Hong , Hainan Lan , Yumeng Li ...
来源:[J].General and Comparative Endocrinology(IF 2.823), 2016, Vol.229, pp.67-73
摘要:... Thus, we analysed primate growth hormone (human growth hormone (hGH)) or non-primate GH (porcine growth hormone (pGH))-induced intracellular signalling in 3T3-F442A cells and rat hepatocytes in a dose- and time-dependent manner to explore the different biological activities b...
作者:Donald T Ward
来源:[J].Cell Calcium(IF 4.327), 2003, Vol.35 (3), pp.217-228
摘要:Abstract(#br)As a G protein-coupled receptor (GPCR), the extracellular calcium-sensing receptor (CaR) responds to changes in extracellular free calcium concentration by inducing intracellular signalling. These CaR-induced signals then specifically modulate cellular functions such...
作者:Pedro Pablo González , Maura Cárdenas , David Camacho ...
来源:[J].BioSystems(IF 1.581), 2003, Vol.68 (2), pp.171-185
摘要:Abstract(#br)The theory of behaviour-based systems (or autonomous agents) constitutes a useful approach for the modelling of intracellular signalling networks. In this sense, a cell can be seen as an adaptive autonomous agent or as a society of such agents, where each can exhibit...
作者:Liu Yao-xia , Chen Jing-yan , Tang Xia-lian ...
来源:[J].General and Comparative Endocrinology(IF 2.823), 2017, Vol.248, pp.49-54
摘要:... In this article, the intracellular signalling profiles between these two hormones were examined. Western blot analyses were performed in 3T3-F442A and CHO cells transfected with GHR (CHO-GHR). The results revealed that both 22K-GH and 20K-GH can activate Janus kinase 2 (JAK2...

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