全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Yuejun Chen , Jingyuan Cao , Man Xiong ...
来源:[J].Cell Stem Cell(IF 25.315), 2015, Vol.17 (2), pp.233-244Elsevier
摘要:Summary(#br)Precise temporal control of gene expression or deletion is critical for elucidating gene function in biological systems. However, the establishment of human pluripotent stem cell (hPSC) lines with inducible gene knockout (iKO) remains challenging. We explored build...
作者:Changbin Li , Yan Ge , Lance Dworkin ...
来源:[J].The Journal of Pathology(IF 7.585), 2016, Vol.239 (1), pp.23-35Wiley
摘要:... Mechanistically, actin cytoskeleton integrity in podocytes was largely preserved in GSK3β knockout mice following ADR insult, concomitant with a correction of podocyte hypermotility and lessened phosphorylation and activation of paxillin, a focal adhesion‐associated a...
来源:[J].Proceedings of the National Academy of Sciences of the United States of America(IF 9.737), 2016, Vol.113 (13), pp.3645-3650JSTOR
摘要:Currently available inducible Cre/loxP systems, despite their considerable utility in gene manipulation, have pitfalls in certain scenarios, such as unsatisfactory recombination rates and deleterious effects on physiology and behavior. To overcome these limitations, we designed a...
作者:Saam J R , Gordon J I
来源:[J].Journal of Biological Chemistry(IF 4.651), 1999, Vol.274 (53), pp.38071-82PubMed
摘要:We have developed two systems for performing Cre-mediated recombination of target genes in the rapidly self-renewing mouse small intestinal and colonic epithelium. When expression of Cre recombinase is placed directly under the control of transcriptional regulatory elements fr...
作者:赵珞
来源:[D].北京协和医学院  2013CNKI
摘要:研究背景及目的:骨重建的过程包括骨吸收和骨形成两个过程。IGF-1与骨量的获得密切相关,血清IGF-1主要影响皮质骨的生长,而基质IGF-1则与小梁骨的获得密切相关。目前IGF-1在体内环境下对骨髓间充质干细胞...
被引频次:-下载频次:27
作者:Chen Yuejun , Cao Jingyuan , Xiong Man ...
来源:[J].Cell stem cell, 2015, Vol.17 (2), pp.233-44PubMed
摘要:Precise temporal control of gene expression or deletion is critical for elucidating gene function in biological systems. However, the establishment of human pluripotent stem cell (hPSC) lines with inducible gene knockout (iKO) remains challenging. We explored building iKO hPSC li...

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