全部文献期刊会议图书|学者科研项目
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作者:Lourdes Cortes-Dericks , Ralph Alexander Schmid
来源:[J].Respiratory Research(IF 3.642), 2017, Vol.18 (1)
摘要:... The interaction of CD44 with its ligand, hyaluronan (HA) has demonstrated an important role in modulating cell proliferation and invasiveness in MPM. In particular, the high expression levels of these molecules have shown diagnostic relevance in MPM. This review will summariz...
作者:Spyros S. Skandalis , Theodoros Karalis , Paraskevi Heldin
来源:[J].Seminars in Cancer Biology(IF 7.436), 2020, Vol.62, pp.20-30
摘要:Abstract(#br)Hyaluronan-rich matrices are abundant in ECM and are involved in biological processes, such as cell growth and migration. Hyaluronan is synthesized by the hyaluronan synthase family of enzymes, HAS1, HAS2 and HAS3; the HAS1 and HAS3 genes give rise to different trans...
作者:Warren Knudson , Shinya Ishizuka , Kenya Terabe ...
来源:[J].Matrix Biology(IF 3.19), 2019, Vol.78-79, pp.32-46
摘要:Abstract(#br)The story of hyaluronan in articular cartilage, pericellular hyaluronan in particular, essentially is also the story of aggrecan. Without properly tethered aggrecan, the load bearing function of cartilage is compromised. The anchorage of aggrecan to the cell surface...
作者:Shambo Bhattacharya , Devendra K. Dubey
来源:[J].Journal of the Mechanical Behavior of Biomedical Materials(IF 2.368), 2020
摘要:... This work presents a mechanistic understanding of the effect of hydration, closely associated with aggrecan degradation, on the nanoscale mechanical behaviour of the hyaluronan present in the EFM of the Annulus Fibrosus. For this purpose, explicit three-dimensional molec...
作者:Byong-Gon Park , Chang Won Lee , Joo Woong Park ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2015, Vol.467 (4), pp.623-628
摘要:Abstract(#br)Hyaluronan has diverse biological activities depending on its molecular size. High molecular weight hyaluronan (2000 kDa) is a major component of extracellular matrix, and has been used in wounding healing, extracellular matrix regeneration, and in the treatment of...
作者:Theodoros T. Karalis , Paraskevi Heldin , Demitrios H. Vynios ...
来源:[J].Matrix Biology(IF 3.19), 2019, Vol.78-79, pp.118-138
摘要:Abstract(#br)The malignant phenotype of various cancers is linked to enhanced expression of hyaluronan, a pro-angiogenic glycosaminoglycan whose expression is suppressed by 4-methylumbelliferone (4-MU), a non-toxic oral agent used as a dietary supplement to improve health and ...
作者:Markku I. Tammi , Sanna Oikari , Sanna Pasonen-Seppänen ...
来源:[J].Matrix Biology(IF 3.19), 2019, Vol.78-79, pp.147-164
摘要:Abstract(#br)Hyaluronan accumulates in the stroma of several solid tumors and promotes their progression. Both enhanced synthesis and fragmentation of hyaluronan are required as a part of this inflammatory process resembling wound healing. Increased expression of the genes of hyaluronan...
作者:Tereza Venerová , Miloslav Pekař
来源:[J].Carbohydrate Polymers(IF 3.479), 2017, Vol.170, pp.176-181
摘要:... The effects of hyaluronan molecular weight (from 300 to 2 kDa) and the concentration of initial solutions (0.5 and 2% for hyaluronan, 50 or 200 mM for surfactant) were investigated. All systems demonstrated viscoelastic properties which can be modified over a broad range ...
作者:Fuxin Wang , Hsun-Ming Chang , Yuyin Yi ...
来源:[J].Cellular Signalling(IF 4.304), 2019, Vol.63
摘要:Abstract(#br)Hyaluronan serves as a structural component of ovarian follicles, and hyaluronan-mediated signaling cascades lead to follicular development, oocyte maturation, and ovulation. Transforming growth factor-β (TGF-β1) is highly expressed in human oocytes and granul...
作者:Meng Sha , Wang Yao , Xiao Zhang ...
来源:[J].Tetrahedron Letters(IF 2.397), 2017, Vol.58 (30), pp.2910-2914
摘要:Abstract(#br)Hyaluronan is a glycosaminoglycan with a large number of biological activity. Hyaluronan of different molecular weight often shows different biological activity, sometimes even completely opposite, but the mechanism is not clear. Herein, the hyaluronan tetrasaccharid...

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