全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Zhang WW , Bai F , Wang J ...
来源:[J].Drug Design, Development and Therapy(IF 3.486), 2017, Vol.Volume 11, pp.3019-3033DOAJ
摘要:... The purpose of this study was to demonstrate whether treatment with an antioxidant compound, edaravone, reduces cardiac fibrosis and improves ventricular function by inhibiting Ang II AT1 receptor. The study was conducted in a rat model of transverse aortic constriction (...
作者:Bin Dai , Ting Yan , Yi-xing Shen ...
来源:[J].Neural Regeneration Research(IF 0.144), 2017, Vol.12 (2), pp.283-289DOAJ
摘要:... We hypothesized that edaravone, a low molecular weight, lipophilic free radical scavenger, would reduce OGSD/R-induced apoptosis of spinal cord astrocytes. To test this, we established primary cultures of rat astrocytes, and exposed them to 8 hours/6 hours of OGSD/R with or ...
作者:Noriko Nakajima , Shinichi Watanabe , Takeshi Kiyoi ...
来源:[J].Journal of Pharmacological Sciences(IF 2.15), 2015, Vol.127 (3), pp.339-343Elsevier
摘要:... We focused on the antioxidant effects of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one; Radicut ® ). Oral mucositis was induced on the tongue tips of mice using a single dose of X-rays (20 Gy). To evaluate the protective effect of edaravone (30 and 300 mg/kg), administr...
作者:Sharma Pawan , Sinha Manish , Shukla R ...
来源:[J].Annals of Indian Academy of Neurology(IF 0.928), 2011, Vol.14 (2), pp.103-106DOAJ
摘要:Background and Objective: Edaravone has potent antioxidant and free radical scavenger properties. Few Japanese studies had demonstrated its neuroprotective role in acute ischemic stroke (AIS). This study aims to evaluate the efficacy of edaravone in terms of functional outcom...
作者:Arzu Toruk Aksar , Nursen Yuksel , Mustafa Gok ...
来源:[J].International Journal of Ophthalmology(IF 0.119), 2015, Vol.8 (2), pp.239-244DOAJ
摘要:AIM: To evaluate the neuroprotective activity of systemically administered edaravone in early and late stage of experimental glaucoma in rats. METHODS: In this study, 60 Wistar albino rats were used. Experimental glaucoma model was created by injecting hyaluronic acid to the ante...
作者:Somasundaram Arumugam , Rajarajan A. Thandavarayan , Punniyakoti T. Veeraveedu ...
来源:[J].Journal of Cellular and Molecular Medicine(IF 4.753), 2012, Vol.16 (9), pp.2176-2185Wiley
摘要:Abstract(#br)Edaravone, a novel antioxidant, acts by trapping hydroxyl radicals, quenching active oxygen and so on. Its cardioprotective activity against experimental autoimmune myocarditis ( EAM ) was reported. Nevertheless, it remains to be determined whether edaravone prot...
作者:Z Sun , Q Xu , G Gao ...
来源:[J].Nigerian Journal of Clinical Practice(IF 0.263), 2019, Vol.22 (10), pp.1324-1327Wolters Kluwer
摘要:... The edaravone is a new antioxidant and hydroxyl radical scavenger, which is the novel scavenger for clinical use, mainly for nervous system diseases. Objective: The purpose of this study is to observe the clinical treatment effects of edaravone on the degree of improvement ...
作者:Renan Sukmawan , Toyotaka Yada , Eiji Toyota ...
来源:[J].Journal of Pharmacological Sciences(IF 2.15), 2007, Vol.104 (4), pp.341-348Elsevier
摘要:Abstract(#br)We examined whether edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a free radical scavenger, exerts its protective effect on coronary microvessels after ischemia/reperfusion (I/R) in vivo. Ninety-minute coronary occlusion followed by reperfusion was performed in...
作者:Yuko Takayasu , Junko Nakaki , Toshiyuki Kawasaki ...
来源:[J].Journal of Pharmacological Sciences(IF 2.15), 2007, Vol.103 (4), pp.434-437Elsevier
摘要:Abstract(#br)Edaravone, a radical scavenger, prevents ischemia/reperfusion injury in the brain, but the detailed mechanism is not known. This study examines the effect of edaravone on mitochondrial permeability transition pore (PTP) in rat brain. Edaravone at 10 – 100 µ M inh...
作者:Cakmak Neziha Hacihasanoglu , Yanardag Refiye
来源:[J].Journal of the Serbian Chemical Society(IF 0.912), 2015, Vol.80 (5), pp.627-637DOAJ
摘要:...Edaravone (EDA; 3-methyl-1-phenyl-2-pyrazoline-5-one) is a potent freeradical scavenger. In this study, we aimed to investigate the effects of EDAon VPA-induced hepatic damage. Male Sprague Dawley rats were divided intofour groups. Group I was control animals. Group II was con...

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