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作者:Jifeng Deng , Peng Liu , Bijun Lv ...
来源:[J].Journal of Pharmaceutical and Biomedical Analysis(IF 2.947), 2015, Vol.111, pp.204-208
摘要:Abstract(#br)The unclear etiology of Alzheimer's disease leaves a large space for drug exploration. A novel anti-neuroinflammation agent (ZW14) was previously determined to have comparable efficacy to the marketed drug (donepezil) in the A β -induced model mice. Herein, a se...
作者:Paul Worms , Jean-Paul Kan , Camille C. Wermuth ...
来源:[J].Naunyn-Schmiedeberg's Archives of Pharmacology(IF 2.147), 1986, Vol.334 (3), pp.246-252
摘要:Summary(#br)The behavioural effects of CM 30366, an aminopyridazine derivative, on dopamine-mediated neurotransmissions, have been studied in mice and rats. CM 30366 induced stereotyped behaviour and antagonized haloperidol-induced catalepsy in rats, after parenteral and oral adm...
作者:Gottfried Heinisch , Alfred Hetzenauer , Barbara Matuszczak ...
来源:[J].Journal of Heterocyclic Chemistry(IF 1.224), 2001, Vol.38 (4), pp.945-948
摘要:Abstract(#br)Reaction of 3‐aminopyridazine ( 1 ) with 2‐mefhylphenylisocyante ( 4 ) affords not only the desired urea derivative ( 5 ) but also an unexpected side‐product ( 6 ), which could be identified as the corresponding biuret derivative by means of elemental and spe...
作者:Jeffrey M. Craft , D.Martin Watterson , Sally A. Frautschy ...
来源:[J].Neurobiology of Aging(IF 6.166), 2004, Vol.25 (10), pp.1283-1292
摘要:... We report that late intervention with a recently discovered aminopyridazine suppressor of glial activation, developed to inhibit both oxidative and inflammatory cytokine pathways, attenuates human amyloid beta (Aβ)-induced glial activation in a murine model. Peripheral ...
作者:Chanh P H , Lasserre B , Kaiser R ...
来源:[J].Prostaglandins, leukotrienes, and essential fatty acids(IF 2.732), 1990, Vol.40 (2), pp.143-8
摘要:Experiments carried out under the conditions adopted showed the strong affinity of aminopyridazine derivatives for the eicosanoids TXA2 and PGI2. But this affinity depended on the chemical structure of the molecule: a small change in the radical grafted onto the pyridazine ring c...
作者:Schumacher C , Steinberg R , Kan J P ...
来源:[J].European journal of pharmacology(IF 2.592), 1989, Vol.166 (2), pp.139-47
摘要:In order to design a selective M1 muscarinic agonist, we synthesized SR 95639A (morpholinoethylamino-3-benzocyclohepta-(5,6-c)-pyridazine, dihydrochloride), a semi-rigid analogue of the aminopyridazine antidepressant drug minaprine. SR 95639A displaced [3H]pirenzepine from its bi...
作者:Sisir Nandi , Mohd. Salman
来源:[J].Research and Reports in Medicinal Chemistry, 2015, Vol.2015 (default), pp.49-60
摘要:Quantitative structure-activity relationship and pharmacophore models have been developed in the present study to predict mode of binding of highly active aminopyridazine derivatives of γ-aminobutyric acid acting as selective GABA-A receptor antagonists against induced coma....

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