全部文献期刊会议图书|学者科研项目
中外文文献  中文文献  外文文献
作者:Hala Hussein , Fidaa Ibrahim , Eugène Sobngwi ...
来源:[J].Clinical Biochemistry(IF 2.45), 2017, Vol.50 (1-2), pp.94-96
摘要:Abstract(#br)Objectives(#br)Zinc transporter 8 (ZnT8) is specifically expressed in the pancreatic β-cell and is more restricted in its tissue distribution than other auto-antigens as glutamic acid decarboxylase 65 (GAD 65 ) and insulinoma-associated antigen-2 (IA2). ZnT8 auto...
作者:Shufa Li , Haiying Li , Bing Chen ...
来源:[J].Vaccine(IF 3.492), 2013, Vol.31 (12), pp.1610-1615
摘要:Abstract(#br)Numerous evidences demonstrated that type 1 diabetes (T1D) is due to a loss of immune tolerance to islet antigens, and CD8 + T cells play an important role in the development of T1D. Zinc Transporter 8 (ZnT8) has emerged in recent years as a target of disease-as...
作者:Anita Rogowicz-Frontczak , Stanisław Pilacinski , Krystyna Wyka ...
来源:[J].Diabetes Research and Clinical Practice(IF 2.741), 2018, Vol.146, pp.313-320
摘要:Abstract(#br)Aim(#br)The study aimed to assess the prevalence of zinc transporter 8 autoantibodies (ZnT8-ab), other diabetes-related autoantibodies and clinical manifestation of type 1 diabetes in adults, depending on age of the onset of disease.(#br)Methods(#br)119 patients wit...
作者:Xiuli Zhang , Tingwen Guan , Boxuan Yang ...
来源:[J].Metabolism(IF 3.096), 2018, Vol.88, pp.40-50
摘要:Abstract(#br)Objective(#br)Zinc is intimately involved in testosterone production. Zinc transporter 8 (ZnT8) is found to be localized in insulin secretory granules as a β-cell specific Zn transporter. The effect of ZnT8 and related zinc accumulation in steroidogenesis, howeve...
作者:Gareth Dunseath , Rossitza Ananieva-Jordanova , Rebecca Coles ...
来源:[J].Clinica Chimica Acta(IF 2.85), 2015, Vol.447, pp.90-95
摘要:Abstract(#br)Aims(#br)A bridging-type ELISA for measuring autoantibodies to zinc transporter 8 (ZnT8A) was assessed using samples from different forms of diabetes mellitus.(#br)Methods(#br)ZnT8A were measured using an ELISA in patients with type 1 diabetes mellitus (T1DM; n = ...
作者:Howard W. Davidson , Janet M. Wenzlau , Richard M. O’Brien
来源:[J].Trends in Endocrinology & Metabolism(IF 8.901), 2014, Vol.25 (8), pp.415-424
摘要:Human pancreatic β cells have exceptionally high zinc content. In β cells the highest zinc concentration is in insulin secretory granules, from which it is cosecreted with the hormone. Uptake of zinc into secretory granules is mainly mediated by zinc transporter 8 (ZnT8), th...
作者:Eiji Kawasaki , Kan Nakamura , Genpei Kuriya ...
来源:[J].Clinical Immunology(IF 3.771), 2010, Vol.138 (2), pp.146-153
摘要:Abstract(#br)The aim of this study was to evaluate the humoral autoreactivity to zinc transporter 8 (ZnT8) depending on the clinical phenotype of type 1 diabetes (T1D). ZnT8 autoantibodies (ZnT8A) were determined by radioimmunoassay using carboxy-terminal ZnT8 constructs in 57 ch...
作者:V. L. Rudland , C. Pech , A. J. Harding ...
来源:[J].Diabetic Medicine(IF 3.241), 2015, Vol.32 (3), pp.359-366
摘要:Abstract(#br)Aims(#br)To investigate the prevalence, clinical significance and antepartum to postpartum trajectory of zinc transporter 8 autoantibodies, a novel marker of islet autoimmunity, in women with gestational diabetes mellitus.(#br)Methods(#br)A total of 302 consecuti...
作者:Xinyu Xu , Yong Gu , Lingling Bian ...
来源:[J].Vaccine(IF 3.492), 2016, Vol.34 (6), pp.854-862
摘要:Abstract(#br)Objective(#br)ZnT8-specific CD8+ T cells in human type 1 diabetes (T1D) have been reported recently, although the results from different laboratories are inconsistent. We aimed to characterize these ZnT8 specific CD8+ T cells and validate assays to screen peptide li...
作者:J. Dereke , C. Nilsson , M. Landin‐Olsson ...
来源:[J].Diabetic Medicine(IF 3.241), 2012, Vol.29 (12), pp.e436-e439
摘要:... A recently identified autoantigen in Type 1 diabetes is zinc transporter 8. Some reports suggest that the frequency of zinc transporter 8 antibodies is as high as glutamic acid decarboxylase antibodies in Type 1 diabetes and thus a good diagnostic marker for autoimmune di...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×