全部文献期刊会议图书|学者科研项目
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作者:Yuhu He , Pu Zou , Yufei Lu ...
来源:[J].Journal of Molecular and Cellular Cardiology(IF 5.148), 2020, Vol.139, pp.1-13
摘要:... OPG promoted neointimal hyperplasia and human aortic smooth muscle cell (hASMC) proliferation and migration through activation of yes-associated protein (YAP), a major downstream effector of the Hippo signaling pathway, whereas knockdown or inhibition of YAP in hASMCs blun...
作者:Shih-Han Huang , Ching-Yu Lin , Yung-Hsi Kao ...
来源:[J].Phytomedicine(IF 2.972), 2020
摘要:... MWA and Western blot analysis indicated that GRT treatment suppressed the protein level of yes-associated protein (YAP), macrophage stimulating 1 protein (MST1), phospho-MST1/phospho-MST2 T180/T183, and paxillin, but increased the abundance of E-cadherin. Over-expression of YAP...
作者:Annaïg Hamon , Diana García-García , Divya Ail ...
来源:[J].Cell Reports, 2019, Vol.27 (6), pp.1712-1725.e6
摘要:... In our quest toward the identification of molecular cues that may boost their stemness potential, we investigated the involvement of the Hippo pathway effector YAP (Yes-associated protein), which is upregulated in Müller cells following retinal injury. Conditional Yap dele...
作者:Qingting Wang , Wenhua Shi , Qianqian Zhang ...
来源:[J].Life Sciences(IF 2.555), 2020, Vol.242
摘要:Abstract(#br)Aims(#br)It has been shown that up-regulation of E3 ubiquitin ligase seven-in-absentia-homolog 2 (Siah2) and activation of Hippo signaling pathway effector yes-associated protein (YAP) are involved in the development of pulmonary arterial hypertension (PAH). Howe...
作者:Li Cheng , Baoming Wu , Lei Zhang ...
来源:[J].Cellular Signalling(IF 4.304), 2020, Vol.65
摘要:... Next, a series of in vitro and in vivo assays were performed to determine the positive feedback loop between gankyrin and YAP in OS.(#br)Results(#br)We first reported that gankyrin is upregulated in human OS specimens and cell lines and predicts OS progression and poor progn...
作者:Francesca Reggiani , Giulia Gobbi , Alessia Ciarrocchi ...
来源:[J].BBA - Reviews on Cancer(IF 9.033), 2020
摘要:... YAP and TAZ transcriptional cofactors behave as oncogenes in different cancer types. Deregulation of YAP/TAZ expression or alterations in components of the multiple signaling pathways converging on these factors are important mechanisms of resistance to chemotherapy, target t...
作者:Lulu Fu , Dong Li , Tiezhu Mi ...
来源:[J].Science of the Total Environment(IF 3.258), 2020, Vol.703
摘要:... Here, we collected core sediment samples of Southern Yap Trench with the deep-sea manned submersible Jiaolong and analyzed the microbial community structure and abundance in the samples through high-throughput sequencing and real-time fluorescence quantitative PCR (qPCR)...
作者:Ayman Husari , Thorsten Steinberg , Martin Philipp Dieterle ...
来源:[J].Cellular Signalling(IF 4.304), 2019, Vol.63
摘要:Abstract(#br)The HIPPO pathway effector YAP has been shown to be regulated by FAK-signaling. However, the existence of an inverse relationship between YAP and FAK is unknown. Here we demonstrate in hMSCs and in the human osteosarcoma derived cell line Saos that Verteporfin- or R...
作者:Marie Angele Cucci , Alessandra Compagnone , Martina Daga ...
来源:[J].Free Radical Biology and Medicine(IF 5.271), 2019, Vol.141, pp.205-219
摘要:Abstract(#br)The transcriptional regulator YAP plays an important role in cancer progression and is negatively controlled by the Hippo pathway. YAP is frequently overexpressed in human cancers, including bladder cancer. Interestingly, YAP expression and activity can be inhibited ...
作者:Yefim Zaltsman , Sayaka Masuko , Joshua J. Bensen ...
来源:[J].Stem Cell Reports, 2019, Vol.12 (5), pp.869-877
摘要:... Substrate elasticity can induce differentiation by signaling through the transcriptional coactivator Yes-associated protein (YAP). Cells cultured on surfaces mimicking brain elasticity exclude YAP from their nuclei and differentiate to neurons. How YAP localization is control...

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