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作者:Sabine A. Richards , Christian Stutzer , Anna-Mari Bosman ...
来源:[J].Ticks and Tick-borne Diseases(IF 2.353), 2015, Vol.6 (6), pp.695-710
摘要:... The importance of transmembrane proteins as vaccine targets are well known, as is the case in tick vaccines with Bm86 as antigen. In this study, we describe the localization and functional annotation of 878 putative transmembrane proteins. Thirty proteins could be confirmed i...
作者:Gábor E. Tusnády , László Dobson , Peter Tompa
来源:[J].BBA - Biomembranes(IF 3.389), 2015, Vol.1848 (11), pp.2839-2848
摘要:Abstract(#br)The functions of transmembrane proteins in living cells are widespread; they range from various transport processes to energy production, from cell–cell adhesion to communication. Structurally, they are highly ordered in their membrane-spanning regions, but may co...
作者:Gokcen Cilingir , Audrey O.T. Lau , Shira L. Broschat
来源:[J].Journal of Microbiological Methods(IF 2.161), 2013, Vol.95 (3), pp.313-319
摘要:Abstract(#br)Background(#br)Computational identification of apicoplast-targeted proteins is important in drug target determination for diseases such as malaria. While there are established methods for identifying proteins with a bipartite signal in multiple species of Apicomplexa...
作者:Chi Zhang , Yingxin Gao
来源:[J].Journal of Biomechanics(IF 2.716), 2014, Vol.47 (12), pp.3232-3236
摘要:Abstract(#br)Lateral transmission of force from myofibers laterally to the surrounding extracellular matrix (ECM) via the transmembrane proteins between them is impaired in old muscles. Changes in geometrical and mechanical properties of ECM of skeletal muscle do not fully expla...
作者:Annette Granéli , Jason J. Benkoski , Fredrik Höök
来源:[J].Analytical Biochemistry(IF 2.582), 2007, Vol.367 (1), pp.87-94
摘要:... For small water-soluble biomolecules, the surface immobilization is quite straightforward, but it has been shown to be difficult for large transmembrane proteins. In those cases, the solid surface often has a negative influence on the function of the transmembrane proteins. I...
作者:Lisa L. Freeman-Cook , Ann M. Dixon , Jennifer B. Frank ...
来源:[J].Journal of Molecular Biology(IF 3.905), 2004, Vol.338 (5), pp.907-920
摘要:Abstract(#br)Growth factor receptors are typically activated by the binding of soluble ligands to the extracellular domain of the receptor, but certain viral transmembrane proteins can induce growth factor receptor activation by binding to the receptor transmembrane domain. F...
作者:Scott A. Houck , Douglas M. Cyr
来源:[J].BBA - Biomembranes(IF 3.389), 2012, Vol.1818 (4), pp.1108-1114
摘要:Abstract(#br)To prevent the accumulation of misfolded and aggregated proteins, the cell has developed a complex network of cellular quality control (QC) systems to recognize misfolded proteins and facilitate their refolding or degradation. The cell faces numerous obstacles when p...
作者:Yasser Qutub , Ilya Reviakine , Carrie Maxwell ...
来源:[J].Journal of Molecular Biology(IF 3.905), 2004, Vol.343 (5), pp.1243-1254
摘要:Crystallization of membrane proteins is a major stumbling block en route to elucidating their structure and understanding their function. The novel concept of membrane protein crystallization from lipidic cubic phases, “ in cubo ”, has yielded well-ordered crystals and high-...
作者:Heon Yung Gee , Jiyoon Kim , Min Goo Lee
来源:[J].Seminars in Cell and Developmental Biology(IF 6.202), 2018
摘要:Abstract(#br)Over the past 20 years it has become evident that eukaryotic cells utilize both conventional and unconventional pathways to deliver proteins to their target sites. Most proteins with a signal peptide and/or a transmembrane domain are conventionally transported throug...
作者:S.B. Marchioro , S. Simionatto , V. Galli ...
来源:[J].Veterinary Microbiology(IF 3.127), 2011, Vol.155 (1), pp.44-52
摘要:... In this study, we cloned17 genes coding for transmembrane proteins from M. hyopneumoniae , among which six were successfully expressed in Escherichia coli and had their immunogenic and antigenic properties evaluated. All proteins were immunogenic in mice and sera from natural...

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