全部文献期刊会议图书|学者科研项目
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作者:Michael A. Cozart , Kevin D. Phelan , Hong Wu ...
来源:[J].Scientific Reports(IF 2.927), 2020, Vol.10 (2), pp.127-138
摘要:... Canonical transient receptor potential 3 (TRPC3) channels are integral to the propagation of seizures in SE, and vascular smooth muscle cell (VSMC) TRPC3 channels participate in vasoconstriction. Therefore, we hypothesize that cerebrovascular TRPC3 channels may contribute to ...
作者:Barbora Svobodova , Michaela Lichtenegger , Dieter Platzer ...
来源:[J].Cell Calcium(IF 4.327), 2019, Vol.79, pp.27-34
摘要:Abstract(#br)Mutation of a single residue within the recently identified lipid (diacylglycerol) recognition window of TRPC3 (G652A) was found to abolish channel activation via endogenous lipid mediators while retaining sensitivity to the non-lipid activator GSK1702934A (abb. GSK)...
作者:Lingwei Wang , Jie Li , Jian Zhang ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2017, Vol.484 (1), pp.209-217
摘要:... Transient receptor potential canonical 3 (TRPC3) has been implicated in diverse functions of airway smooth muscle cells (ASMCs) in asthma. However, the underlying mechanisms remain incompletely understood. We investigated the mRNA and protein expression of TRPC3 in ASMCs ...
作者:Petros Andrikopoulos , Suzanne A. Eccles , Muhammad M. Yaqoob
来源:[J].Cellular Signalling(IF 4.304), 2017, Vol.37, pp.12-30
摘要:... Here we investigated whether Na + influx via the diacylglycerol (DAG) – activated non-selective cation channel TRPC3 was functionally associated with NCX and whether its activity was required for VEGF-induced ERK1/2 activation and angiogenesis. We provide evidence that TRPC3...
作者:Naoyuki Kitajima , Takuro Numaga-Tomita , Masahiko Watanabe ...
来源:[J].Scientific Reports(IF 2.927), 2016, Vol.6 (418), pp.1675-1680
摘要:... We demonstrate that transient receptor potential canonical 3 (TRPC3), a Ca2+-permeable channel, acts as a positive regulator of ROS (PRROS) in cardiomyocytes, and specifically regulates pressure overload-induced maladaptive cardiac remodeling in mice. TRPC3 physica...
作者:Hisako Ishise , Barrett Larson , Yutaka Hirata ...
来源:[J].Scientific Reports(IF 2.927), 2015, Vol.5 (Suppl 1), pp.283-289
摘要:... TRPC3 is highly expressed in human hypertrophic scar tissue and mechanical stimuli are known to upregulate TRPC3 expression in human skin fibroblasts in vitro . TRPC3 overexpressing fibroblasts subjected to repetitive stretching forces showed robust expression levels of ...
作者:Tianyi Ma , Shaoyang Lin , Bin Wang ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2019, Vol.519 (4), pp.674-681
摘要:... Transient receptor potential channel, canonical 3(TRPC3), located in mitochondria, regulates mitochondrial calcium and reactive oxygen species(ROS) production. Herein, we investigated whether TRPC3 participates in high salt-induced cardiac hypertrophy by impairing cardiac...
作者:Chen Jing , Zheng Dongming , Cui Hong ...
来源:[J].Cellular Physiology and Biochemistry(IF 3.415), 2018, Vol.45 (1), pp.378-388
摘要:Background/Aims: To detect the expression of the TRPC3 channel protein in the tissues of women experiencing preterm labor and investigate its interaction with T lymphocytes, providing a theoretical basis for the clinical prevention of threatened preterm labor and the development ...
作者:Prabhatchandra R. Dube , Lakshmikanth L. Chikkamenahalli , Lutz Birnbaumer ...
来源:[J].Atherosclerosis(IF 3.706), 2018, Vol.270, pp.199-204
摘要:Abstract(#br)Background and aims(#br)Recent in vitro studies have showed that in macrophages, deletion of the non-selective Ca 2+ -permeable channel TRPC3 impairs expression of the osteogenic protein BMP-2. The pathophysiological relevance of this effect in atherosclerotic plaqu...
作者:Kayoko Oda , Masanari Umemura , Rina Nakakaji ...
来源:[J].The Journal of Physiological Sciences(IF 1.089), 2017, Vol.67 (4), pp.497-505
摘要:... We show here that Transient receptor potential, canonical 3 (TRPC3) is widely expressed in human melanoma. We found that pharmacological inhibition of TRPC3 with a pyrazole compound, Pyr3, decreased melanoma cell proliferation and migration. Similar inhibition was observed wh...

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