全部文献期刊会议图书|学者科研项目
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作者:Pampa Saha , Sukanya Sarkar , Paidi Ramesh Kumar ...
来源:[J].Brain Behavior and Immunity(IF 5.612), 2020
摘要:... Analysis of the secreted proteins in Aβ-ACM revealed a marked increase of Tissue inhibitor of Metalloproteinase-1(TIMP-1) within 6 h. Interestingly, we found that neutralization of TIMP-1 with antibody or knockdown with siRNA in astrocytes abolished most of the neuroprote...
作者:Anca Remes , Maximilian Franz , Marcin Zaradzki ...
来源:[J].Journal of Heart and Lung Transplantation(IF 5.112), 2020, Vol.39 (4), pp.389-398
摘要:...(#br)METHODS(#br)Aortic allografts from DBA/2 mice were incubated with control buffer, AAV-enhanced green fluorescence protein (EGFP), or tissue inhibitor of metalloproteinases 1 (TIMP-1)-loaded AAV (AAV-TIMP-1) and transplanted into the infrarenal aorta of C57BL/6 mice. Cyclo...
作者:M E Taube , X-W Liu , R Fridman ...
来源:[J].Oncogene(IF 7.357), 2006, Vol.25 (21), pp.3041-3048
摘要:Abstract(#br)Increasing evidence suggests that tissue inhibitor of metalloproteinases-1 (TIMP-1) can directly regulate cell growth and apoptosis independent of its matrix metalloproteinases (MMPs)-inhibitory activity. While TIMP-1's antiapoptotic activity has been well demonstrat...
作者:Achim Krüger , Otto H Sanchez-Sweatman , David C Martin ...
来源:[J].Oncogene(IF 7.357), 1998, Vol.16 (18), pp.2419-2423
摘要:... We generated transgenic mice as a model system to test the relationship between TIMP-1 levels in a host organ and susceptibility to experimentally targeted metastasis. Ectopically overexpressed TIMP-1 in the brain resulted in a tissue microenvironment with elevated protein le...
作者:Haixia Xu , Shaoquan Zhang , Xingfei Pan ...
来源:[J].International Immunopharmacology(IF 2.417), 2016, Vol.38, pp.233-237
摘要:... TIMP-1 is an important regulator in the synthesis and degradation of ECM. IL-32, a multi-function cytokine, could induce IL-1β, IL-6, IL-8 and other cytokine expressions by activating AP-1, NF-κβ, p38MAPK signal pathways. IL-32 expression is increased in liver tissues of...
作者:Sang-A Park , Min-Jin Kim , So-Yeon Park ...
来源:[J].Scientific Reports(IF 2.927), 2015, Vol.5 (1), pp.212-236
摘要:... We identified tissue inhibitors of metalloproteinases-1 (TIMP-1) as one of the secreted proteins of hepatic stellate cells (HSCs) and a key mediator of TGF-β-mediated crosstalk between HSCs and HCC cells. TGF-β signaling led to increased expression of TIMP-1, which activat...
作者:Yinglong Sa , Chao Li , Hongbin Li ...
来源:[J].Cellular Physiology and Biochemistry(IF 3.415), 2015, Vol.35 (6), pp.2233-2243
摘要:Background/Aims: Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been reported to upregulate in urethral scar. However, the underlying molecular mechanisms remain undefined. Methods: Here, we studied levels of TIMP-1 and α-smooth muscle actin (α-SMA) in the fibroblasts i...
作者:Karen-Lise Garm Spindler , Ib Jarle Christensen , Hans Jørgen Nielsen ...
来源:[J].Tumor Biology(IF 2.518), 2015, Vol.36 (6), pp.4301-4308
摘要:... The aim of the present study was to investigate the clinical value of TIMP-1 in patients with metastatic colorectal cancer (mCRC) treated with cetuximab and irinotecan. Patients with chemotherapy-resistant mCRC referred to third-line treatment with cetuximab (initial 400...
作者:Ying-Hua Chang , Yi-Jen Chiu , Hung-Chi Cheng ...
来源:[J].Tumor Biology(IF 2.518), 2015, Vol.36 (5), pp.3957-3967
摘要:Abstract(#br)Tissue inhibitor metalloproteinase-1 (TIMP-1) is clinically associated with a poor prognosis for various cancers, but the roles of TIMP-1 in lung cancer metastasis are controversial. Our previous secretomic study revealed that TIMP-1 is highly abundant in high invasi...
作者:P. Kuvaja , S. Hulkkonen , I. Pasanen ...
来源:[J].Experimental Cell Research(IF 3.557), 2012, Vol.318 (10), pp.1094-1103
摘要:Abstract(#br)Tissue inhibitor of metalloproteinases-1 (TIMP-1) is shown to be a potential marker for poor prognosis in breast cancer, but the biology of TIMP-1 is only partially understood. In this study, TIMP-1 production was studied in a co-culture model of hormone-independ...

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