全部文献期刊会议图书|学者科研项目
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作者:Jiang Man , Kefei Cui , Xiaojie Fu ...
来源:[J].Brain Research(IF 2.879), 2020, Vol.1736
摘要:... Src/Pyk-2 is one of the downstream pathways of acetylcholine receptors (AchRs), and has been shown to participate in the activation of fibroblast growth factor receptor (FGFR)/epidermal growth factor receptor (EGFR) signaling in cancer cells. In this study, we investigated...
作者:Dimitrios Toumpanakis , Vyronia Vassilakopoulou , Ioanna Sigala ...
来源:[J].Respiratory Research(IF 3.642), 2017, Vol.18 (1)
摘要:... Src is a multifunctional kinase that is activated in the lung by mechanical stress. ERK1/2 kinase is a downstream target of Src. We hypothesized that Src is activated in the lung during IRB, mediates ERK1/2 activation and IRB-induced lung injury.
作者:Kentaro Tanaka , Yuko Ito , Kentaro Kajiwara ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2020
摘要:Abstract(#br)Upregulation of the Src tyrosine kinase is implicated in the progression of cancer. The oncogenic potential of Src is suppressed via several negative regulation systems including degradation via the ubiquitin–proteasome pathway. Here, we show that ubiquitination o...
作者:Xuexiang Ying , Anling Huang , Yajing Xing ...
来源:[J].Science China Life Sciences(IF 2.024), 2017, Vol.60 (4), pp.417-428
摘要:... Furthermore, on mechanism, lycorine inhibited tumor cell migration and invasion via blocking the Src/FAK (focal adhesion kinase)-involved pathway. In conclusion, our study implied lycorine was a potential candidate for the treatment of breast cancer by inhibition of tumor gro...
作者:Yang Yang , Xiaoliang Dong , Shuangning Zheng ...
来源:[J].Redox Biology, 2020, Vol.30
摘要:... Our findings demonstrated a novel mechanism that GSTpi inhibited VE-cadherin phosphorylation through suppressing the activation of Src/VE-cadherin pathway. Mass spectrometry analysis and molecular docking showed that GSTpi enhanced Src S-glutathionylation at Cys185, Cys245, a...
作者:Yin-Ying Lu , Xue-Ke Zhao , Lei Yu ...
来源:[J].Scientific Reports(IF 2.927), 2017, Vol.7 (1), pp.775-785
摘要:Abstract(#br)Src kinase is known to regulate fibroblast migration. However, the contribution of integrin and Src kinase interaction to lung fibrosis has not been mechanistically investigated. Our data demonstrate that integrin alpha v (αV) recruited Src kinase and that lea...
作者:Kai Dai , Zubing Chen , Sha She ...
来源:[J].Immunobiology(IF 2.814), 2020
摘要:... Further experiments revealed that LRCH1 knockout enhanced the activation of Src and Lck kinase which are important for natural killer cell cytotoxicity. The in vivo assay confirmed the up-regulation of the tumoricidal activity of LRCH1-/- NK-92 cells, as demonstrated by mor...
作者:A. Rodrigues , L.J.R. Nunes
来源:[J].Fuel(IF 3.357), 2020, Vol.269
摘要:Abstract(#br)This work intended to compare ash composition and deposition tendencies biomasses and of torrefied products of SRC poplar clones and common broom. These biomasses were assessed in a previous study as these delivering torrefied products with better fuel quality. As...
作者:Hanpei Ma , Chunxu Yao , Peng Ma ...
来源:[J].Scientific Reports(IF 2.927), 2019, Vol.9 (1), pp.7687-7692
摘要:Abstract(#br)Src family of kinases (SFKs) has been found to play an important role in the regulation of nociception. However, how each member of this family acts in the central nervous system (CNS) structures involved in the relay and/or modulation of nociceptive signals, and...
作者:Jae Gon Kim , Young-Eun Leem , Ilmin Kwon ...
来源:[J].Experimental & Molecular Medicine(IF 2.573), 2018, Vol.50 (Suppl 4), pp.1-9
摘要:... Serotonin increased Src activation in arterial smooth muscle required for contraction, which was significantly inhibited by E2. The estrogen receptor-independent inhibition of Src by E2 was confirmed in HEK293T cells that do not express estrogen receptor. Taken together, th...

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