全部文献期刊会议图书|学者科研项目
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作者:Chen Jianwen , Pan Kaiyuan , Chen Zhen ...
来源:[J].Animal science journal = Nihon chikusan Gakkaiho, 2019
摘要:... In this study, we applied site-specific editing pAPN which is effective in swine testis (ST) cells. Site-specific editing of pAPN reduced TGEV proliferation in ST cells by 96%-99% at different time periods post-infection. Next, the site-specific editing of pAPN porcine fetal ...
作者:Lualdi Susanna , Del Zotto Genny , Zegarra-Moran Olga ...
来源:[J].Human mutation, 2017, Vol.38 (7), pp.849-862
摘要:The transfer of genomic information into the primary RNA sequence can be altered by RNA editing. We have previously shown that genomic variants can be RNA-edited to wild-type. The presence of distinct "edited" iduronate 2-sulfatase (IDS) mRNA transcripts ex vivo evidenced the cor...
作者:Michael Piechotta , Emanuel Wyler , Uwe Ohler ...
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (1)
摘要:RNA editing is a co-transcriptional modification that increases the molecular diversity, alters secondary structure and protein coding sequences by changing the sequence of transcripts. The most common RNA editing modification is the single base substitution ( A → I ) that...
作者:Angela Gallo , Dragana Vukic , David Michalík ...
来源:[J].Human Genetics(IF 4.633), 2017, Vol.136 (9), pp.1265-1278
摘要:... ADAR1 is widely expressed, particularly in the myeloid component of the blood system, and plays a prominent role in promiscuous editing of long dsRNA. Missense mutations that change ADAR1 residues and reduce RNA editing activity cause Aicardi–Goutières Syndrome, a chil...
作者:Rosalind Brookfield , Felix Dafhnis-Calas , Zhengyao Xu ...
来源:[J].Transgenic Research(IF 2.609), 2012, Vol.21 (5), pp.1125-1136
摘要:Abstract(#br)We have investigated the practicality of implementing a strategy for site-specific editing by homologous recombination in zebrafish analogous to that developed by Rong and Golic (Rong and Golic in Genetics 157:1307–1312, 2001 ) in Drosophila melanogaster . We ...
作者:蘇奕臣(Yi-Chen Su) , 黃鵬林(Pung-Ling Huang) , 杜宜殷(Yi-Yin Do)
来源:[J].臺灣園藝, 2016, Vol.62 (4), pp.201-212
摘要:In the recent decade, scientists put more attention on genome site-specific editing technologies, such as transcription activator-like effector nucleases (TALEN) and zinc finger nuclease (ZFN). Recently, a new method based on bacterial clustered regularly interspaced short palind...
作者:Lejun Ouyang , Mingsai Ma , Limei Li
来源:[J].Biotechnology Letters(IF 1.853), 2020, Vol.42 (1), pp.313-318
摘要:Abstract(#br)Objective(#br)To obtain transgene-free progeny by constructing a DNA editing system with a fluorescent screening marker gene and two pairs of single-guide RNAs to simultaneously recognize two different sites in the target gene encoding Arabidopsis microRNA( miR)160 A...
作者:Yulia Lampi , Dominique Van Looveren , Lenard S. Vranckx ...
来源:[J].Scientific Reports(IF 2.927), 2019, Vol.9 (1), pp.503-505
摘要:... We used site-specific editing of the PSIP1 locus using CRISPR/Cas to target the aspartic acid residue in position 366 and mutated it to asparagine (D366N) to disrupt the interaction with HIV IN but retain LEDGF/p75 cellular function. The resulting cell lines demonstrated succ...
作者:Zuyong He , Chris Proudfoot , C. Bruce A. Whitelaw ...
来源:[J].SpringerPlus, 2016, Vol.5 (1), pp.1-12
摘要:... To date few comparative studies have been carried out to investigate the difference of genome editing characteristics between CRISPR/Cas9 and TALENs. While the CRISPR/Cas9 system has overtaken TALENs as the tool of choice for most research groups working in this field, we hyp...
作者:Michael F. Steinburg , Delores Schock , John W. Backus ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 1999, Vol.263 (1), pp.81-86
摘要:Abstract(#br)Site-specific editing of apolipoprotein B (apoB) mRNA by the cytidine deaminase, APOBEC-1 is proposed to require interactions of auxiliary protein(s) with an eleven nucleotide element, the mooring sequence, located 3′ of the C → U editing site. An analysis o...

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