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作者:Sensen Li , Longfeng Jiang , Yanbing Yang ...
来源:[J].Experimental and Molecular Pathology(IF 2.128), 2020, Vol.113
摘要:Abstract(#br)It has been documented that sialic acid-binding Ig-like lectin 1 (Siglec1) is a cell surface protein with a variety of functions in the immune system. In the present study, we evaluated whether Siglec1 plays a role in chronic obstructive pulmonary disease (COPD). Re...
作者:Qingliang Zheng , Jin Hou , Ye Zhou ...
来源:[J].Cell Research(IF 10.526), 2015, Vol.25 (10), pp.1121-1136
摘要:... Here, we found that the expression of lectin family member Siglec1 was upregulated by viral infection in macrophages, which was dependent on the IFN/JAK/STAT1 signaling pathway. Siglec1 was found to negatively regulate viral infection-triggered type I IFN production. Mechanis...
作者:Dhemerson Souza de Lima , Vinicius C.L. Nunes , Mauricio M. Ogusku ...
来源:[J].Infection, Genetics and Evolution(IF 2.768), 2017, Vol.55, pp.313-317
摘要:... In the lung, the expression of Siglec-1 is specific for alveolar macrophages and single nucleotide polymorphisms (SNPs) in SIGLEC1 have been recently associated with asthma severity.(#br)Taking in account the role of alveolar macrophages in the control of M. tuberculosis and...
作者:S Malhotra , J Castilló , MF Bustamante ...
来源:[J].Multiple Sclerosis Journal(IF 4.472), 2013, Vol.19 (5), pp.524-531
摘要:...(#br)Objective:(#br)The purpose of this study was to investigate the role of two members of the Siglec family, SIGLEC1 and SIGLEC7, in the clinical course and disease activity of patients with multiple sclerosis (MS).(#br)Methods:(#br)SIGLEC1 and SIGLEC7 expression was de...
作者:Lisney Anna R , Szelinski Franziska , Reiter Karin ...
来源:[J].Annals of the rheumatic diseases, 2017, Vol.76 (8), pp.1476-1480
摘要:... SIGLEC1 expression was measured by flow cytometry and was correlated to plasma IFN-α levels measured by ELISA, and IFN-γ-induced protein 10 (IP-10) levels measured by Bio-Plex technique.(#br)RESULTS(#br)Mothers of affected children had a significantly higher expression of SIGLEC1...
作者:Zheng Qingliang , Hou Jin , Zhou Ye ...
来源:[J].Cell research, 2015, Vol.25 (10), pp.1121-36
摘要:... Here, we found that the expression of lectin family member Siglec1 was upregulated by viral infection in macrophages, which was dependent on the IFN/JAK/STAT1 signaling pathway. Siglec1 was found to negatively regulate viral infection-triggered type I IFN production. Mechanis...
作者:Prather Randall S , Rowland Raymond R R , Ewen Catherine ...
来源:[J].Journal of virology, 2013, Vol.87 (17), pp.9538-46
摘要:Surface expression of SIGLEC1, also known as sialoadhesin or CD169, is considered a primary determinant of the permissiveness of porcine alveolar macrophages for infection by porcine reproductive and respiratory syndrome virus (PRRSV). In vitro, the attachment and internalization...
作者:Malhotra S , Castilló J , Bustamante Mf ...
来源:[J].Multiple sclerosis (Houndmills, Basingstoke, England), 2013, Vol.19 (5), pp.524-31
摘要:...(#br)OBJECTIVE(#br)The purpose of this study was to investigate the role of two members of the Siglec family, SIGLEC1 and SIGLEC7, in the clinical course and disease activity of patients with multiple sclerosis (MS).(#br)METHODS(#br)SIGLEC1 and SIGLEC7 expression was determine...

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