全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Te-Hui Kuo , Wei-Hung Lin , Jo-Yen Chao ...
来源:[J].BMC Nephrology(IF 1.644), 2019, Vol.20 (1), pp.1-10DOAJ
摘要:Abstract Background Sclerostin, an antagonist of the Wingless-type mouse mammary tumor virus integration site (Wnt) pathway that regulates bone metabolism, is a potential contributor of chronic kidney disease (CKD)–mineral and bone disorder (MBD), which has various forms of ...
作者:Piotr Kuczera , Marcin Adamczak , Andrzej Więcek
来源:[J].BMC Nephrology(IF 1.644), 2016, Vol.17 (1)Springer
摘要:Abstract(#br) Background(#br)Sclerostin is a paracrine acting factor, which is expressed in the osteocytes and articular chondrocytes. Sclerostin decreases the osteoblast-related bone formation through the inhibition of the Wnt/β-catenin pathway. Osteocytes also express the ...
作者:Saima Zameer , Divya Vohora
来源:[J].Pharmacological Reports(IF 1.965), 2017Elsevier
摘要:... Further, in view of the reports of estrogen and Wnt signaling pathway in cognition, the role of two Wnt signaling antagonists (dickkopf-1 and sclerostin) in mediation of cognitive effects of aromatase inhibitors was evaluated.(#br)Methods(#br)Three behavioral paradigms we...
作者:Manouk Dam , Floor Neelemaat , Trudeke Struijk-Wielinga ...
来源:[J].BMC Nephrology(IF 1.644), 2017, Vol.18 (1)Springer
摘要:... A second aim is to assess the influence of NHD on the biomarkers fibroblast growth factor-23 and sclerostin which are thought to be associated with malnutrition and mortality in patients on haemodialysis.
作者:Gabriella Császárné Gombos , Viktória Bajsz , Emese Pék ...
来源:[J].BMC Musculoskeletal Disorders(IF 1.875), 2016, Vol.17 (1)Springer
摘要:... Changes in bone-specific alkaline phosphatase (BALP), carboxy-terminal cross-linked telopeptide of type I collagen (CTX), and serum sclerostin concentrations were measured before and immediately after a single exercise intervention.(#br) Results(#br)There was no significa...
作者:Hung-Wei Liao , Tsang-Hai Huang , Yi-Han Chang ...
来源:[J].International Journal of Molecular Sciences(IF 2.464), 2019, Vol.20 (8)DOAJ
摘要:... Osteocyte-derived sclerostin inhibits the osteogenic Wnt/β-catenin signaling pathway; its levels rise when kidney function declines. Exercise modulates the physiological functions of osteocytes, potentially altering sclerostin production. It may aid bone and mineral elec...
作者:Katelin R. Haynes , Hsu-Wen Tseng , Michaela Kneissel ...
来源:[J].BMC Musculoskeletal Disorders(IF 1.875), 2015, Vol.16 (1)Springer
摘要:... Several recent studies have shown that sclerostin (SOST), a Wnt inhibitor specific to osteocytes and chondrocytes, is down-regulated in AS patients. This suggests Wnt signalling may be upregulated, and application of exogenous recombinant SOST (rSOST) may inhibit Wnt signalli...
作者:A Zagrodna , P Jóźków , M Mędraś ...
来源:[J].Biology of Sport(IF 0.415), 2016, Vol.33 (1), pp.83-87DOAJ
摘要:Sclerostin is a protein secreted by osteocytes that acts as an inhibitor of bone formation. It has been shown that physical activity affects sclerostin concentration and thus bone remodelling. The aim of the study was to evaluate serum concentrations of sclerostin, selected bone...
作者:Thor Ueland , Lis Stilgren , Jens Bollerslev
来源:[J].International Journal of Molecular Sciences(IF 2.464), 2019, Vol.20 (12)DOAJ
摘要:... Secreted pathway modulators such as sclerostin (SOST) and Dickkopfs (DKKs) may influence bone mass inhibiting the canonical Wnt pathway. We evaluated whether bone protein content of secreted Wnt antagonists is related to age, bone mass, and strength in postmenopausal ost...
作者:Marco Bonani , Daniel Rodriguez , Thomas Fehr ...
来源:[J].Kidney & Blood Pressure Research(IF 1.596), 2014, Vol.39 (4), pp.230-239DOAJ
摘要:Background/Aims: Sclerostin is secreted by osteocytes. As a circulating inhibitor of the Wnt-signaling pathway it inhibits bone formation and contributes to the development of osteoporosis. Sclerostin levels are elevated in patients with chronic kidney disease and end-stage ...

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