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作者:Cristina Ros-Carrero , Lucía Ramos-Alonso , Antonia María Romero ...
来源:[J].BBA - Gene Regulatory Mechanisms(IF 5.456), 2020, Vol.1863 (7)
摘要:... Here, we describe a mechanism that optimizes the activity of yeast ribonucleotide reductase when iron is scarce. We demonstrate that Aft1 and the DNA-binding protein Ixr1 enhance the expression of the gene encoding for its catalytic subunit, RNR1 , in response to iron limitat...
作者:Michael S Myette , Howard L Elford , Christopher R Chitambar
来源:[J].Cancer Letters(IF 4.258), 1998, Vol.129 (2), pp.199-204
摘要:Abstract(#br)Ribonucleotide reductase, a key enzyme in deoxyribonucleotide synthesis, is an important target for cancer chemotherapy. Drugs that inhibit its individual components may act synergistically to block DNA synthesis. Prior work has established that gallium inhibits the ...
作者:Malin Uppsten , Mathias Färnegårdh , Vladimir Domkin ...
来源:[J].Journal of Molecular Biology(IF 3.905), 2006, Vol.359 (2), pp.365-377
摘要:Ribonucleotide reductase is an indispensable enzyme for all cells, since it catalyses the biosynthesis of the precursors necessary for both building and repairing DNA. The ribonucleotide reductase class I enzymes, present in all mammals as well as in many prokaryotes and DNA ...
作者:Andrew B. Das , Izabela Sadowska-Bartosz , Andreas Königstorfer ...
来源:[J].Free Radical Biology and Medicine(IF 5.271), 2018, Vol.116, pp.114-122
摘要:Abstract(#br)Ribonucleotide reductase (RNR) catalyses the rate limiting step of DNA synthesis utilising a mechanism that requires a tyrosyl radical. We have previously shown that superoxide can quench protein tyrosyl radicals in vitro , either by oxidative addition, or reduction ...
作者:Rotem Cohen , Shira Milo , Sushma Sharma ...
来源:[J].DNA Repair(IF 4.274), 2019, Vol.83
摘要:Abstract(#br)Ribonucleotide reductase (RNR) catalyzes the rate limiting step in dNTP biosynthesis and is tightly regulated at the transcription and activity levels. One of the best characterized responses of yeast to DNA damage is up-regulation of RNR transcription and activity a...
作者:Martin D. Burkhalter , Steven A. Roberts , Jody M. Havener ...
来源:[J].DNA Repair(IF 4.274), 2009, Vol.8 (11), pp.1258-1263
摘要:... Cellular dNTP pools are regulated primarily by changes in ribonucleotide reductase activity. We show that an inhibitor of ribonucleotide reductase (hydroxyurea) hypersensitizes NHEJ-deficient cells, but not wild type or HR-deficient cells, to chromosome breaks introduced by i...
作者:Sylvie Camier , Emilie Ma , Christophe Leroy ...
来源:[J].Free Radical Biology and Medicine(IF 5.271), 2006, Vol.42 (7), pp.1008-1016
摘要:Abstract(#br)Thioredoxins and/or glutaredoxins assist ribonucleotide reductase, and other such enzymes that require disulfide bond reduction during their catalytic cycle. In Saccharomyces cerevisiae , the presence of either pathway is essential but which of these pathways opera...
作者:Naoaki Fujii , Benjamin J. Evison , Marcelo L. Actis ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2015, Vol.23 (21), pp.6912-6921
摘要:... In a screen against compounds that are classified as inhibitors of DNA repair or synthesis, the reporter generation was exquisitely sensitive to ribonucleotide reductase (RNR) inhibitors such as gemcitabine and clofarabine, but not to inhibitors of PARP, ATR, ATM, Chk1, and o...
作者:Mikael Crona , Paula Codó , Venkateswara Rao Jonna ...
来源:[J].Molecular Oncology(IF 6.701), 2016, Vol.10 (9), pp.1375-1386
摘要:Abstract(#br)Ribonucleotide Reductase (RNR) is the sole enzyme that catalyzes the reduction of ribonucleotides into deoxyribonucleotides. Even though RNR is a recognized target for antiproliferative molecules, and the main target of the approved drug hydroxyurea, few new leads ta...
作者:Mukundan Baskar Mannargudi , Subrata Deb
来源:[J].Journal of Cancer Research and Clinical Oncology(IF 2.914), 2017, Vol.143 (8), pp.1499-1529
摘要:Ribonucleotide reductase (RR) enzymes (RR1 and RR2) play an important role in the reduction of ribonucleotides to deoxyribonucleotides which is involved in DNA replication and repair. Augmented RR activity has been ascribed to uncontrolled cell growth and tumorigenic transformati...

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