全部文献期刊会议图书|学者科研项目
中外文文献  中文文献  外文文献
作者:Tim Niehues , Ruy Perez-Becker , Catharina Schuetz
来源:[J].Clinical Immunology(IF 3.771), 2010, Vol.135 (2), pp.183-192Elsevier
摘要:Abstract(#br)Combined immunodeficiencies with impaired numbers and function of T- and B-cells can be attributed to defects in the recombinase activating genes (RAG). The products of these genes, the RAG1 and 2 proteins, are key players in the V(D)J recombination process leading...
作者:Anna Villa , Luigi D. Notarangelo
来源:[J].Immunological Reviews(IF 12.155), 2019, Vol.287 (1), pp.73-90Wiley
摘要:Summary(#br)Mutations of the recombinase activating genes ( RAG ) in humans underlie a broad spectrum of clinical and immunological phenotypes that reflect different degrees of impairment of T‐ and B‐cell development and alterations of mechanisms of central and peripheral...
作者:Tong-Gang Wang , Lonnie Lybarger , Rachel Soloff ...
来源:[J].Molecular Immunology(IF 2.645), 1996, Vol.33 (11), pp.957-964Elsevier
摘要:... There they undergo maturation through a series of developmental steps that include rearrangement and expression of the TCR genes, positive and negative selection, and functional maturation. Although these intrathymic processes have been extensively characterized, little is...
作者:Anne M. Murray , Brett Simm , Kenneth W. Beagley
来源:[J].Cytokine(IF 2.518), 1998, Vol.10 (5), pp.337-345Elsevier
摘要:... In the studies reported here, the authors have analysed cytokine/growth factor gene expression, recombinase-activating gene RAG-1 and RAG-2 gene expression and terminal deoxynucleotidyl transferase (TdT) gene expression in mouse fetal intestine and fetal thymus and liver, ...
作者:Rebecca H. Buckley
来源:[J].The Journal of Allergy and Clinical Immunology(IF 12.047), 2010, Vol.125 (4), pp.790-797Elsevier
摘要:Although bone marrow transplantation has resulted in life-saving T-cell reconstitution in infants with severe combined immunodeficiency (SCID), correction of B-cell function has been more problematic. This review examines B-cell reconstitution results presented in 19 reports from...
作者:Edward G Brooks
来源:[J].BioSystems(IF 1.581), 1999, Vol.54 (1), pp.31-37Elsevier
摘要:... Detecting these abnormalities in surviving pools of lymphocytes is difficult and typically focuses on identification of abnormally rearranged alleles or on detecting abnormalities in recombinase proteins. Thus, there currently exists no rapid screening method to identify ab...
作者:Adrian M. Casillas , Andrew D. Thompson , Samuel Cheshier ...
来源:[J].Molecular Immunology(IF 2.645), 1995, Vol.32 (3), pp.167-175Elsevier
摘要:Abstract(#br)Expression of the recombination activating genes, RAG -1 and RAG -2, in lymphocytes, has been shown to depent on second messenger systems. An increase in in intracellular cAMP upon stimulation with caffeine increases RAG expression while activation of protein kinase ...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×