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作者:Allison M Manuel , Michael D Walla , Gerardo G Piroli ...
来源:[J].Free Radical Biology and Medicine(IF 5.271), 2017, Vol.112, pp.151-151
摘要:... Fumarate can react with protein thiols to form the chemical modification S-(2-succino) cysteine (2SC), also termed protein succination. Succination is significantly increased in the adipose tissue of type 2 diabetic mouse models, and in adipocytes matured in high glucose, res...
作者:Gianluca Miglio , Alessandro Damiano Sabatino , Eleonora Veglia ...
来源:[J].BBA - Proteins and Proteomics(IF 3.733), 2016, Vol.1864 (2), pp.211-218
摘要:Abstract(#br)The adduction of fumaric acid to the sulfhydryl group of certain cysteine (Cys) residues in proteins via a Michael-like reaction leads to the formation of S -(2-succino)cysteine (2SC) sites. Although its role remains to be fully understood, this post-translational Cy...
作者:Mar Llamas-Velasco , Luis Requena , Julie Adam ...
来源:[J].The American Journal of Dermatopathology(IF 1.418), 2016
摘要:AIMS:: Hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome is an autosomal dominant disorder caused by heterozygotic germline mutations in fumarate hydratase (FH) with incomplete penetrance, and clinically challenging to diagnose. Immunohistochemical stainings m...
作者:Piroli Gerardo G , Manuel Allison M , Walla Michael D ...
来源:[J].The Biochemical journal, 2014, Vol.462 (2), pp.231-45
摘要:Protein succination is a stable post-translational modification that occurs when fumarate reacts with cysteine residues to generate 2SC [S-(2-succino)cysteine]. We demonstrate that both α- and β-tubulin are increasingly modified by succination in 3T3-L1 adipocytes and in t...
作者:Gianluca Miglio
来源:[J].Amino Acids(IF 3.914), 2018, Vol.50 (5), pp.647-652
摘要:... The reactivity of cysteines found in fumarate-sensitive proteins was predicted when the collected data for eight network-type features were analyzed using classification models. Therefore, methods for evaluating the likelihood of a cysteine site to be modified by fumarate cou...
作者:Llamas-Velasco Mar , Requena Luis , Adam Julie ...
来源:[J].The American Journal of dermatopathology, 2016, Vol.38 (12), pp.887-891
摘要:AIMS(#br)Hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome is an autosomal dominant disorder caused by heterozygotic germline mutations in fumarate hydratase (FH) with incomplete penetrance, and clinically challenging to diagnose. Immunohistochemical stainings may ...
作者:Allison M. Manuel , Michael D. Walla , Margaret T. Dorn ...
来源:[J].Free Radical Biology and Medicine(IF 5.271), 2020, Vol.148, pp.70-82
摘要:Abstract(#br)C/EBP homologous protein (CHOP) is a transcription factor that is elevated in adipose tissue across many models of diabetes and metabolic stress. Although increased CHOP levels are associated with the terminal response to endoplasmic reticulum stress and apoptosis...
作者:Allison M. Manuel , Norma Frizzell
来源:[J].Amino Acids(IF 3.914), 2013, Vol.45 (5), pp.1243-1247
摘要:Abstract(#br)Protein succination , the non-enzymatic modification of cysteine residues by fumarate, is distinguishable from succinylation , an enzymatic reaction forming an amide bond between lysine residues and succinyl-CoA. Treatment of adipocytes with 30 mM glucose significant...
作者:Ross M. Tanis , Gerardo G. Piroli , Stani D. Day ...
来源:[J].BBA - Molecular Cell Research(IF 4.808), 2015, Vol.1853 (1), pp.213-221
摘要:... We also assessed the requirement for the Unfolded Protein Response (UPR) and ER stress under these conditions. Basal respiration was ~ 1.7-fold greater in adipocytes that had matured in 30 mM glucose; however, their ability to increase oxygen consumption in response to stress...

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