全部文献期刊会议图书|学者科研项目
中外文文献  中文文献  外文文献
作者:Emil Spreitzer , Sinem Usluer , Tobias Madl
来源:[J].Journal of Molecular Biology(IF 3.905), 2020
摘要:Abstract(#br)Proteins and their interactions control a plethora of biological functions and enable life. Protein–protein interactions can be highly dynamic, involve proteins with different degrees of “foldedness,” and are often regulated through an intricate network of pos...
作者:Varlamova Elena Gennadyevna
来源:[J].Biochimie(IF 3.142), 2020
摘要:Abstract(#br)ER is a highly specialized complex of branched microtubules enclosed in a membrane and communicating with each other, its functions in the cell are important and very diverse: lipid and phospholipid synthesis, calcium storage, hormone synthesis, protein synthesis...
作者:Katherine E. Brechun , Katja M. Arndt , G. Andrew Woolley
来源:[J].Journal of Molecular Biology(IF 3.905), 2018
摘要:Abstract(#br)We have developed a genetic circuit in Escherichia coli that can be used to select for protein–protein interactions of different strengths by changing antibiotic concentrations in the media. The genetic circuit links protein–protein interaction strength to ...
作者:Long Zhang , Guoxian Yu , Dawen Xia ...
来源:[J].Neurocomputing(IF 1.634), 2018
摘要:Abstract(#br)Protein–protein interactions (PPIs) are of vital importance to most biological processes. Plenty of PPIs have been identified by wet-lab experiments in the past decades, but there are still abundant uncovered PPIs. Furthermore, wet-lab experiments are expensive a...
作者:Mohd Quadir Siddiqui , Yogendra S. Rajpurohit , Pankaj S. Thapa ...
来源:[J].International Journal of Biological Macromolecules(IF 2.596), 2017, Vol.104, pp.1338-1344
摘要:... A set of FA pathway proteins mainly FANCI, FANCD2 and BRCA2 are expressed to repair the covalent crosslink between the dsDNA. However, FA, BRCA pathways play an important role in DNA ICL repair as well as in homologous recombination repair, but the presumptive role of FA-B...
作者:Baoguang Tian , Xue Wu , Cheng Chen ...
来源:[J].Journal of Theoretical Biology(IF 2.351), 2019, Vol.462, pp.329-346
摘要:Abstract(#br)Research on protein–protein interactions (PPIs) not only helps to reveal the nature of life activities but also plays a driving role in understanding the mechanisms of disease activity and the development of effective drugs. The rapid development of machine le...
作者:Anna D Cunningham , Nir Qvit , Daria Mochly-Rosen
来源:[J].Current Opinion in Structural Biology(IF 8.738), 2017, Vol.44, pp.59-66
摘要:Protein–protein interactions are essential for almost all intracellular and extracellular biological processes. Regulation of protein–protein interactions is one strategy to regulate cell fate in a highly selective manner. Specifically, peptides are ideal candidates for inh...
作者:Anja Berwanger , Susanne Eyrisch , Inge Schuster ...
来源:[J].Journal of Inorganic Biochemistry(IF 3.197), 2009, Vol.104 (2), pp.118-125
摘要:Abstract(#br)Modulations of protein–protein interactions are a key step in regulating protein function, especially in networks. Modulators of these interactions are supposed to be candidates for the development of novel drugs. Here, we describe the role of the small, polycat...
作者:Yang Xu , Jin Shi , Noboru Yamamoto ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2005, Vol.14 (8), pp.2660-2673
摘要:Abstract(#br)Protein–protein interfaces are prominent in many therapeutically important targets. Using small organic molecules to disrupt protein–protein interactions is a current challenge in chemical biology. An important example of protein–protein interactions is provid...
作者:Arne H. Smits , Michiel Vermeulen
来源:[J].Trends in Biotechnology(IF 9.66), 2016, Vol.34 (10), pp.825-834
摘要:During the past decades, mass spectrometry (MS)-based proteomics has become an important technology to identify protein–protein interactions (PPIs). The application of a quantitative filter in protein enrichments from crude lysates to discriminate bona fide interactors from ...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×