全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Prateep Pakavathkumar , Anastasia Noël , Clotilde Lecrux ...
来源:[J].Molecular Neurodegeneration(IF 4.007), 2017, Vol.12 (1)Springer
摘要:The activation of the aspartate-specific cysteinyl protease, Caspase-6, is proposed as an early pathogenic event of Alzheimer disease (AD) and Huntington’s disease. Caspase-6 inhibitors could be useful against these neurodegenerative diseases but most Caspase-6 inhibitors ha...
作者:Parrisa Solaimani , Arian Saffari , Constantinos Sioutas ...
来源:[J].Neurotoxicology(IF 2.652), 2017, Vol.58, pp.50-57Elsevier
摘要:... Microarray analysis was performed on primary human neurons derived from fetal brain tissue after a 24 h exposure to 20 μg/mL of ambient ultrafine particles. We found a majority of the changes in noncoding RNAs, which are involved in epigenetic regulation of gene expression...
作者:Zhenquan Jia , Hong Zhu , Hara P. Misra ...
来源:[J].Brain Research(IF 2.879), 2007, Vol.1197, pp.159-169Elsevier
摘要:... In this study, we showed that incubation of SH-SY5Y neuroblastoma cells or primary human neurons with micromolar concentrations (10–100 μM) of D3T for 24 h resulted in significant increases in the levels of reduced glutathione (GSH) and NAD(P)H:quinone oxidoreductase 1 (...
作者:Alexzander Asea , Punit Kaur , Alexander Panossian ...
来源:[J].Phytomedicine(IF 2.972), 2013, Vol.20 (14), pp.1323-1329Elsevier
摘要:Abstract(#br)We have previously demonstrated that ADAPT-232, a fixed combination of adaptogenic substances derived from Eleutherococcus senticosus root extract, Schisandra chinensis berry extract, Rhodiola rosea root extract stimulated the expression and release of neuropeptide Y (NPY) and molecular chaperone Hsp72 from isolated human...
作者:Zainulabedin M. Saiyed , Nimisha Gandhi , Marisela Agudelo ...
来源:[J].Neurochemistry International(IF 2.659), 2011, Vol.58 (6), pp.656-664Elsevier
摘要:... More recently, neuron specific overexpression of HDAC2 has been shown to modulate synaptic plasticity and learning behavior in mice. However, the role of HDAC2 in development of HIV-associated neurocognitive disorders (HAND) is not reported. Herein we report that HIV-1 Tat pr...
作者:N. Braidy , A. Matin , F. Rossi ...
来源:[J].Neurotoxicity Research(IF 2.865), 2014, Vol.25 (2), pp.226-234Springer
摘要:... To determine the mechanism of CTX-mediated cytotoxicity in human neurons, we measured extracellular lactate dehydrogenase (LDH) activity, intracellular levels of nicotinamide adenine dinucleotide (NAD + ) and H2AX phosphorylation at serine 139 as a measure for DNA damage in primary...

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