全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Thomas Hoffmann , Antoine Marion , Iris Antes
来源:[J].BMC Structural Biology(IF 2.099), 2018, Vol.17 (1)Springer
摘要:T cell receptor (TCR) molecules are involved in the adaptive immune response as they distinguish between self- and foreign-peptides, presented in major histocompatibility complex molecules (pMHC). Former studies showed that the association angles of the TCR variable domains ...
作者:Yannick Djoumbou-Feunang , Jarlei Fiamoncini , Alberto Gil-de-la-Fuente ...
来源:[J].Journal of Cheminformatics(IF 3.59), 2019, Vol.11 (1), pp.1-25Springer
摘要:Abstract(#br) Background(#br)A number of computational tools for metabolism prediction have been developed over the last 20 years to predict the structures of small molecules undergoing biological transformation or environmental degradation. These tools were largely developed to ...
作者:Yiding Lu , Yufan Guo , Anna Korhonen
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (1)Springer
摘要:In silico drug-target interaction (DTI) prediction plays an integral role in drug repositioning: the discovery of new uses for existing drugs. One popular method of drug repositioning is network-based DTI prediction, which uses complex network theory to predict DTIs from a d...
作者:Xiaoyang Jing , Qiwen Dong , Ruqian Lu
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (1)Springer
摘要:In structural biology area, protein residue-residue contacts play a crucial role in protein structure prediction. Some researchers have found that the predicted residue-residue contacts could effectively constrain the conformational search space, which is significant for de novo ...
作者:Sheng Liu , Cristina Zibetti , Jun Wan ...
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (1)Springer
摘要:Computational prediction of transcription factor (TF) binding sites in different cell types is challenging. Recent technology development allows us to determine the genome-wide chromatin accessibility in various cellular and developmental contexts. The chromatin accessibility pro...
作者:Kuang-Lim Chan , Rozana Rosli , Tatiana V. Tatarinova ...
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (1), pp.1-7Springer
摘要:Gene prediction is one of the most important steps in the genome annotation process. A large number of software tools and pipelines developed by various computing techniques are available for gene prediction. However, these systems have yet to accurately predict all or even most ...
作者:Haiou Li , Jie Hou , Badri Adhikari ...
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (1)Springer
摘要:... Since deep learning was introduced to the field of bioinformatics in 2012, it has achieved success in a number of areas such as protein residue-residue contact prediction, secondary structure prediction, and fold recognition. In this work, we developed deep learning methods t...
作者:Preeti Choudhary , Shailesh Kumar , Anand Kumar Bachhawat ...
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (1)Springer
摘要:... However, experimental identification of catalytic residues is a tedious and time-consuming task, which can be expedited by computational predictions. Despite significant development in active-site prediction methods, one of the remaining issues is ranked positions of putative...
作者:Turki Turki , Zhi Wei
来源:[J].BMC Systems Biology(IF 2.982), 2017, Vol.11 (5)Springer
摘要:... This problem occurs in part because many available drug sensitivity prediction algorithms do not consider better quality cancer cell lines and the adoption of new feature representations; both lead to the accurate prediction of drug responses. By predicting accurate drug resp...
作者:Lin Wang , Xiaozhong Li , Louxin Zhang ...
来源:[J].BMC Cancer(IF 3.333), 2017, Vol.17 (1)Springer
摘要:... Although several methods have been developed to address the drug response prediction, there are many challenges in obtaining accurate prediction.

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