全部文献期刊会议图书|学者科研项目
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作者:R. Rivoirard , A. Vallard , J. Langrand-Escure ...
来源:[J].Cancer / Radiothérapie(IF 1.477), 2016, Vol.20 (8), pp.833-836
摘要:... Thus, if the main purpose of phase I is to determine the dose to use during phase II, methodology should be finely adjusted to experimental treatment(s). Today, the methodology for chemotherapy and targeted therapy is well known. For radiotherapy and chemoradiotherapy phase I...
作者:Dymphy R. H. Huntjens , Sivi Ouwerkerk-Mahadevan , Anne Brochot ...
来源:[J].Clinical Pharmacokinetics(IF 6.109), 2017, Vol.56 (11), pp.1331-1342
摘要:... Here, we report the pharmacokinetics, the population pharmacokinetic modeling, and the safety and tolerability of JNJ-53718678 from the first-in-human, double-blind, randomized, placebo-controlled phase I study.
作者:Chenglong Li , Amitava Mukherjee , Qin Su
来源:[J].Computers & Industrial Engineering(IF 1.516), 2019, Vol.129
摘要:Abstract(#br)In this paper, we introduce an exactly distribution-free procedure for Phase I analysis which is capable of assessing stability of both location and scale parameters of the process using a single plotting statistic. A large proportion of literature on Phase I or retr...
作者:Saddam Akber Abbasi , Nurudeen A. Adegoke
来源:[J].The International Journal of Advanced Manufacturing Technology(IF 1.205), 2018, Vol.99 (5-8), pp.1903-1916
摘要:... Recently, work has been done on monitoring the multivariate coefficient of variation (CV) in phase II of the statistical process control (SPC). However, no study has investigated the performance of the multivariate CV charts in phase I. The phase I procedures are more impo...
作者:John Moroney , Jennifer Wheler , David Hong ...
来源:[J].Gynecologic Oncology(IF 3.929), 2010, Vol.117 (3), pp.467-472
摘要:... We assessed patients with metastatic gynecologic cancers in a dedicated phase I clinical trials clinic in order to determine their outcome.(#br)Methods(#br)We reviewed records for 89 consecutive patients with gynecologic cancers referred to the Phase I Clinical Trials Pro...
作者:Wai Meng Tai , Cindy Lim , Aziah Ahmad ...
来源:[J].Journal of Geriatric Oncology(IF 1.118), 2015, Vol.6 (3), pp.241-248
摘要:Abstract(#br)Background(#br)Despite the significant burden of cancer in the older population, their outcomes in the context of phase I studies have been poorly studied. While the Royal Marsden Hospital (RMH) prognostic score (albumin, lactate dehydrogenase [LDH], number of metas...
作者:Katrina N. Slaughter , Elizabeth K. Nugent , Erin A. Bishop ...
来源:[J].Gynecologic Oncology(IF 3.929), 2014, Vol.132 (1), pp.231-235
摘要:Abstract(#br)Objectives(#br)Previous reviews of phase I clinical trials report limited response rates. Development of novel biologic agents and trials designs have increased these rates. A contemporary appraisal of phase I clinical trials in gynecologic malignancies could help va...
作者:Chunze Li , Priya Agarwal , Ekaterina Gibiansky ...
来源:[J].Clinical Pharmacokinetics(IF 6.109), 2017, Vol.56 (9), pp.1069-1080
摘要:The aim of this study was to evaluate the pharmacokinetics (PK) of trastuzumab emtansine (T-DM1) and relevant analytes in patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer and hepatic impairment.
作者:Sven Kohler , Cordula Zeller , Hristo Iliev ...
来源:[J].Advances in Therapy(IF 2.125), 2017, Vol.34 (7), pp.1707-1726
摘要:We characterized the safety and tolerability of empagliflozin in patients with type 2 diabetes (T2DM) randomized 1:1:1 to placebo, empagliflozin 10 mg, or empagliflozin 25 mg in clinical trials.
作者:Nassim Djebli , Jean-Marie Martinez , Laura Lohan ...
来源:[J].Clinical Pharmacokinetics(IF 6.109), 2017, Vol.56 (10), pp.1155-1171
摘要:Proprotein convertase subtilisin/kexin type 9 inhibition with monoclonal antibodies such as alirocumab significantly reduces low-density lipoprotein-cholesterol levels ± other lipid-lowering therapies. We aimed to develop and qualify a population pharmacokinetics (PopPK) mod...

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