全部文献期刊会议图书|学者科研项目
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作者:Hai-Yan Zhang , Wei Niu , Olajide E. Olaleye ...
来源:[J].Journal of Ethnopharmacology(IF 2.755), 2020, Vol.253
摘要:... Unlike for intravenous route, little is known about the intramuscular pharmacokinetics of herbal compounds. To facilitate rational use of herbal medicine, it is important to better understand such intramuscular pharmacokinetics.(#br)Aim of the study(#br)Bioactive constitu...
作者:Ertugrul Terzi , Orhan Corum , Soner Bilen ...
来源:[J].Aquaculture(IF 2.009), 2020, Vol.520
摘要:Abstract(#br)The pharmacokinetics of danofloxacin was studied in rainbow trout ( Oncorhynchus mykiss ) after single administration by intravenous (IV), intramuscular (IM) and oral (OR) gavage at a dose of 10 mg/kg and by 10 mg/L bath for 2 h at 11.7 ± 0.8 °C. Furthermore, ...
作者:Essam Ezzeldin , Muzaffar Iqbal , Yousif A. Asiri ...
来源:[J].Journal of Chromatography B(IF 2.487), 2020, Vol.1143
摘要:... In this study, we developed a UPLC-MS/MS method to quantify pimavanserin disposition in the brain and its pharmacokinetics in mice. Vilazodone was used as the internal standard. Pimavanserin and IS were extracted by liquid-liquid extraction using tert -butyl methyl ether ...
作者:Kaveri M. Adki , Yogesh A. Kulkarni
来源:[J].Life Sciences(IF 2.555), 2020
摘要:...(#br)Aim(#br)To review chemistry, pharmacokinetics, pharmacological activities as well as various formulations of paeonol.(#br)Materials and methods(#br)A literature search was done using different search terms for paeonol by using different scientific databases like PubMed, S...
作者:Ruth Nabisere , Joseph Musaazi , Paolo Denti ...
来源:[J].Trials(IF 2.206), 2020, Vol.21 (1), pp.2994-2996Springer
摘要:... This study aims to determine the safety of higher doses of rifampicin and its effect on the pharmacokinetics of efavirenz (EFV) and dolutegravir (DTG) in TB-HIV co-infected patients. Methods(#br)This study is a randomized, open-label, phase IIb clinical trial among TB-HIV ...
作者:Khaled Naja , Said El Shamieh , Rajaa Fakhoury
来源:[J].Drug Metabolism and Pharmacokinetics(IF 2.071), 2020, Vol.35 (1), pp.160-164Elsevier
摘要:...(#br)The rs622342A>C in SLC22A1 may be associated with metformin pharmacokinetics and variability in therapeutic efficacy.
作者:Jiarui Gao , Guifang Dou , Xiaoxia Zhu ...
来源:[J].Journal of Chromatography B(IF 2.487), 2020, Vol.1140
摘要:Abstract(#br)As a myricetin derivative, M10 is a potent agent of anti-chronic colonic inflammation. It has better activity than myricetin in preventing azoxymethane/dextran sulfate sodium - induced ulcerative colitis. Here, we introduce a sensitive quantification method base...
作者:Yoichi Naritomi , Seigo Sanoh , Shigeru Ohta
来源:[J].Drug Metabolism and Pharmacokinetics(IF 2.071), 2018, Vol.33 (1), pp.31-39Elsevier
摘要:Abstract(#br)Predicting human drug metabolism and pharmacokinetics (PK) is key to drug discovery. In particular, it is important to predict human PK, metabolite profiles and drug-drug interactions (DDIs). Various methods have been used for such predictions, including in vitro met...
作者:Yumiko Akamine , Masatomo Miura , Hisakazu Komori ...
来源:[J].Drug Metabolism and Pharmacokinetics(IF 2.071), 2015, Vol.30 (5), pp.352-357Elsevier
摘要:Abstract(#br)The stereoselective pharmacokinetics of fexofenadine are associated with OATP2B1-mediated transport, and grapefruit juice (GFJ) is an inhibitor of OATP2B1. Therefore, in this study, we aimed to investigate whether and to what extent GFJ ingestion affected the pharmacokinetics...
作者:Marine Vernant , Marie Lepoupet , Christian Creveuil ...
来源:[J].Trials(IF 2.206), 2020, Vol.21 (1), pp.208-219Springer
摘要:Abstract(#br)Background(#br)Among palliative care (PC) patients who are administered paracetamol, the subcutaneous (SC) route is often an alternative to the intravenous (IV) route. Yet pharmacological and clinical data on whether these are equivalent pharmacokinetically are ...

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