全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Jiani Yuan , Xuanxuan Zhou , Wei Cao ...
来源:[J].Nanoscale Research Letters(IF 2.524), 2017, Vol.12 (1)Springer
摘要:... The objective of this study was to determine the characterization, antitumor efficacy, and pharmacokinetics of bufalin-loaded PEGylated liposomes compared with bufalin entity, which were prepared by FDA-approved pharmaceutical excipients. Bufalin-loaded PEGylated liposome...
作者:Dietmar Hamel , Antonio Bosco , Laura Rinaldi ...
来源:[J].BMC Veterinary Research(IF 1.861), 2017, Vol.13 (1)Springer
摘要:... In addition, the pharmacokinetics of EPN when administered at that dosage to adult sheep was determined.
作者:Jinbin Yuan , Gang Ren , Jian Liang ...
来源:[J].BMC Complementary and Alternative Medicine(IF 2.082), 2017, Vol.17 (1)Springer
摘要:... To further elucidate the detoxification mechanism of honey-processing, comparative pharmacokinetics of AAs in AF and HAF are performed in this study.
作者:Kathrin Buntenkötter , Maren Osmers , Ina Schenk ...
来源:[J].BMC Veterinary Research(IF 1.861), 2016, Vol.13 (1)Springer
摘要:Although acetylsalicylic acid (ASA) is not frequently used as a therapeutic agent in horses, its metabolite SA is of special interest in equestrianism since it is a natural component of many plants used as horse feed. This led to the establishment of thresholds by horse sport org...
作者:Lee WS , Shim SR , Lee SY ...
来源:[J].Drug Design, Development and Therapy(IF 3.486), 2018, Vol.Volume 12, pp.495-504DOAJ
摘要:... Pharmacokinetic data in mice, rats, and cynomolgus monkeys were used to predict the pharmacokinetics of TTAC-0001 in humans using allometric scaling. The predicted serum clearance of TTAC-0001 in humans was 102.45 mL/h and the terminal half-life was 27.52 h. Results: The max...
作者:Yoichi Naritomi , Seigo Sanoh , Shigeru Ohta
来源:[J].Drug Metabolism and Pharmacokinetics(IF 2.071), 2018, Vol.33 (1), pp.31-39Elsevier
摘要:Abstract(#br)Predicting human drug metabolism and pharmacokinetics (PK) is key to drug discovery. In particular, it is important to predict human PK, metabolite profiles and drug-drug interactions (DDIs). Various methods have been used for such predictions, including in vitro met...
作者:Rafiei P , Haddadi A
来源:[J].International Journal of Nanomedicine(IF 3.463), 2017, Vol.Volume 12, pp.935-947DOAJ
摘要:... There are important matters of concern regarding the drug’s pharmacokinetics related to the conventional formulation. Poly(lactide-co-glycolide) (PLGA) is a biocompatible/biodegradable polymer with variable physicochemical characteristics, and its application in human ha...
作者:Céline E. Toutain , Wolfgang Seewald , Martin Jung
来源:[J].Parasites & Vectors(IF 3.246), 2017, Vol.10 (1)Springer
摘要:... The pharmacokinetics of lotilaner were thoroughly determined after intravenous and oral administration and under different feeding regimens in dogs.
作者:Fiona Macintyre , Yeka Adoke , Alfred B. Tiono ...
来源:[J].BMC Medicine(IF 6.679), 2017, Vol.15 (1)Springer
摘要:The clinical development of a single encounter treatment for uncomplicated malaria has the potential to significantly improve the effectiveness of antimalarials. Exploratory data suggested that the combination of artefenomel and piperaquine phosphate (PQP) has the potential ...
作者:Yumiko Akamine , Masatomo Miura , Hisakazu Komori ...
来源:[J].Drug Metabolism and Pharmacokinetics(IF 2.071), 2015, Vol.30 (5), pp.352-357Elsevier
摘要:Abstract(#br)The stereoselective pharmacokinetics of fexofenadine are associated with OATP2B1-mediated transport, and grapefruit juice (GFJ) is an inhibitor of OATP2B1. Therefore, in this study, we aimed to investigate whether and to what extent GFJ ingestion affected the pharmacokinetics...

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