全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Prateep Pakavathkumar , Anastasia Noël , Clotilde Lecrux ...
来源:[J].Molecular Neurodegeneration(IF 4.007), 2017, Vol.12 (1)Springer
摘要:... Caspase-6 inhibitors could be useful against these neurodegenerative diseases but most Caspase-6 inhibitors have been exclusively studied in vitro or show acute liver toxicity in humans. Here, we assessed vinyl sulfone small molecule peptide caspase inhibitors for potential ...
作者:Tayebeh Farhadi
来源:[J].International Journal of Peptide Research and Therapeutics(IF 1.28), 2018, Vol.24 (3), pp.409-420Springer
摘要:... In this study, In silico designing of peptide inhibitors and peptidomimetics against PPIs was done to prevent unwanted drug metabolisms caused by PXR activation. In sum, no designed peptides had considerable higher energy of interactions and more H-bonds with the recepto...
作者:Kuifeng Wang , Chunying Yang , Gang Lin ...
来源:[J].Medicinal Chemistry Research(IF 1.612), 2017, Vol.26 (11), pp.2824-2831Springer
摘要:... In this work, a structure-based rational strategy was described to design peptide inhibitors serving as the interaction disruptors between the preS1 domain of hepatitis B virus large envelope protein and the EAR domain of γ2-adaptin. The binding site of preS1 to γ2-EAR wa...
作者:Neng Xiong , Yanjiao Zhao , Xiaoyan Dong ...
来源:[J].Small(IF 7.823), 2017, Vol.13 (13), pp.n/a-n/aWiley
摘要:... Herein, we proposed to design molecular hybrids of peptide inhibitors by combining two peptide inhibitors, VVIA and LPFFD, into single sequences and examined their effects on Aβ42 aggregation and cytotoxicity. The hybrid peptides exhibit increased but moderat...
作者:Faiza Baameur , Richard A. Hammitt , Jacqueline Friedman ...
来源:[J].International Journal of Peptide Research and Therapeutics(IF 1.28), 2014, Vol.20 (1), pp.1-12Springer
摘要:Abstract(#br)Identifying novel allosteric inhibitors of G protein-coupled receptor kinases (GRKs) would be of considerable use in limiting both the extent of desensitization of GPCRs as well as downstream positive regulation through GRKs. Several peptides have previously been ...
作者:Mingfei Ji , Guodong Zheng , Xiaolong Li ...
来源:[J].Journal of Molecular Modeling(IF 1.984), 2017, Vol.23 (6)Springer
摘要:... The results obtained may help to design the next generation of higher affinity Bcr-Abl SH2-specific peptide inhibitors.
作者:Christine M. Burrer , Glenna W. Foight , Amy E. Keating ...
来源:[J].Virus Research(IF 2.745), 2016, Vol.211, pp.86-88Elsevier
摘要:... In this study, we used two novel peptide inhibitors identified in a peptide library screen that selectively bind KsBcl-2 (KL6-7_Y4eK) or KsBcl-2 and Mcl-1 (MS1) in order to decipher the relative contribution of Mcl-1 and KsBcl-2 in maintaining mitochondrial membrane potentia...
作者:Gkourogianni , Kiouptsi , Koloka ...
来源:[J].Platelets(IF 2.24), 2018, Vol.29 (1), pp.34-40Taylor & Francis
摘要:... It was previously shown that a lipid-modified platelet permeable peptide, which corresponds to the intracellular acidic membrane distal sequence 1000LEEDDEEGE1008 of αIIb (pal-K-LEEDDEEGE or pal-K-1000-1008), inhibits thrombin-induced huma...
作者:Geqing Wang , Nyssa Drinkwater , Damien R. Drew ...
来源:[J].Journal of Molecular Biology(IF 3.905), 2016, Vol.428 (20), pp.3986-3998Elsevier
摘要:... The best mutations improved the binding affinity of the β-hairpin peptide by ~ 7-fold for 3D7 AMA1 and ~ 14-fold for FVO AMA1. We determined the crystal structures of several β-hairpin peptides in complex with AMA1 in order to define the structural features and specific in...
作者:Guanggan Bo , Fang Cao , Min Li ...
来源:[J].Journal of Molecular Graphics and Modelling(IF 2.325), 2019, Vol.93Elsevier
摘要:... Short peptide inhibitors are used to competitively suppress the enzymatic activity of hsPLA 2 . Here, Ca 2+ effect on the intermolecular recognition and interaction between hsPLA 2 and its peptide inhibitors is investigated systematically by using molecular modeling and b...

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