全部文献期刊会议图书|学者科研项目
中外文文献  中文文献  外文文献
作者:Yachen Shen , Yvonne Su , Francisco J. Silva ...
来源:[J].Cell Reports, 2020, Vol.30 (9), pp.3079-3091.e5
摘要:... Agonists for nuclear receptors PPARα and PPARγ both affect brown adipocyte function, yet the interplay between these factors in BAT is uncertain. Here, we report that PPARα shares most genomic binding sites with PPARγ, and these common binding sites are more related to B...
作者:Dan Wei , Lin Liao , Huanjun Wang ...
来源:[J].Life Sciences(IF 2.555), 2020, Vol.247
摘要:... In vitro, canagliflozin increased mitochondrial DNA to nuclear DNA and upregulated the expression of PGC-1α, NRF1, tfam, COX5b, COX8b, Atp5o, and CPT1b mRNA and PGC-1α, NRF1, tfam, COX5b, CPT1b protein in 3T3-L1 adipocytes in a dose-dependent manner, while these increases were inhibited by GW6471, a PPARα...
作者:Xue Wang , Liying Tang , Zhaoqiang Zhang ...
来源:[J].Experimental Eye Research(IF 3.026), 2020, Vol.193
摘要:Abstract(#br)As the peroxisome proliferator – activated receptor alpha (PPARα) agonist, fenofibrate has been widely used to be a good lipid-regulating drug in the clinical application. In this study, we investigated the mechanism by which keratocytes inhibit the corneal n...
作者:Patrick D. McMullen , Sudin Bhattacharya , Courtney G. Woods ...
来源:[J].Toxicology in Vitro(IF 2.65), 2020, Vol.64
摘要:Abstract(#br)In this paper, we evaluate the PPARα signaling network in rats, examining transcriptional responses in primary hepatocytes exposed to a PPARα specific ligand, GW7647. These transcriptomic studies were complemented with ChIP-seq studies of PPARα binding and tr...
作者:Karin J. Stebbins , Alex R. Broadhead , Geraldine Cabrera ...
来源:[J].European Journal of Pharmacology(IF 2.592), 2017, Vol.809, pp.130-140
摘要:Abstract(#br)Peroxisome-proliferator activated receptors (PPAR) are members of the nuclear hormone receptor superfamily which regulate gene transcription. PPARα is a key regulator of lipid homeostasis and a negative regulator of inflammation. Under conditions of metabolic st...
作者:Xiao-Zheng Dou , Dinesh Nath , Younghwa Shin ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2018
摘要:Abstract(#br)Small molecule agonism of PPARα represents a promising new avenue for the development of non-invasive treatments for oculovascular diseases like diabetic retinopathy and age-related macular degeneration. Herein we report initial structure–activity relationships...
作者:Xue Chen , Stephen C. Ward , Arthur I. Cederbaum ...
来源:[J].Toxicology(IF 4.017), 2017, Vol.379, pp.12-21
摘要:... Fibroblast growth factor 21 (FGF21), a PPARα-regulated liver hormone, is involved in hepatic lipid metabolism. Alcoholic and non-alcoholic fatty liver are enhanced in Pparα knockout ( Pparα −/− ) mice. This study investigates the relationship between the PPARα-FGF2...
作者:He Chang , Fayun Zhao , Xinwen Xie ...
来源:[J].Experimental Cell Research(IF 3.557), 2018
摘要:Abstract(#br)Family members of peroxisome proliferator-activated receptors (PPARs), such as PPARγ, have been shown to be effective in regulating T helper 17 (Th17) cell differentiation. However, whether PPARα, another important family member of PPARs, contributes to Th17 c...
作者:Huiying Hua , Manyun Dai , Yishuang Luo ...
来源:[J].Toxicology Letters(IF 3.145), 2018
摘要:... In this study, wild-type and Pparα -null mice were orally administered diet containing 0.05% ANIT to induce chronic cholestasis. Biochemistry, histopathology and serum metabolome analysis exhibited the similar toxic phenotype between wild-type and Pparα -null mice. Bile ac...
作者:Tânia Vieira Madureira , Ivone Pinheiro , Fernanda Malhão ...
来源:[J].Comparative Biochemistry and Physiology, Part B(IF 2.069), 2018, Vol.229
摘要:Abstract(#br)The crosstalk between peroxisome proliferator-activated receptor α (PPARα) and estrogenic pathways are shared from fish to humans. Salmonid fish had an additional genome duplication, and two PPARα isoforms (PPARαBa and PPARαBb) were previously identified. Sin...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×