全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Kaori Takahashi , Daisuke Nishizawa , Shinya Kasai ...
来源:[J].Journal of Pharmacological Sciences(IF 2.15), 2018, Vol.136 (3), pp.107-113Elsevier
摘要:Abstract(#br)Opioid analgesics are widely used for the treatment of moderate to severe pain. The analgesic effects of opioids are well known to vary among individuals. The present study focused on the genetic factors that are associated with interindividual differences in pain an...
作者:N. D. Tsiklauri , I. R. Nozadze , G. P. Gurtskaia ...
来源:[J].Neurophysiology(IF 0.384), 2011, Vol.43 (3), pp.213-216Springer
摘要:... Furthermore, microinjection of the μ-opioid antagonist naloxone into the NRM significantly decreased antinociceptive effects of NSAIDs characterized by the TF and HP latencies on the 1st experimental day. On the 2nd day, naloxone also provided some trend effects in both TF...
作者:Annica Rhodin , Alfhild Grönbladh , Harumi Ginya ...
来源:[J].2013, Vol.6 (1), pp.8BMC
摘要:... This may be partly explained by the presence of single nucleotide polymorphisms (SNPs) in genes encoding molecular entities involved in opioid metabolism and receptor activation. This paper describes the investigation of SNPs in three genes that have a functional impact o...
作者:Shinya Kasai , Masakazu Hayashida , Ichiro Sora ...
来源:[J].Naunyn-Schmiedeberg's Archives of Pharmacology(IF 2.147), 2008, Vol.377 (4-6), pp.269-281Springer
摘要:Abstract(#br)Significant interindividual differences in opioid sensitivity can hamper effective pain treatment and increase the risk for substance abuse. Elucidation of the genetic mechanisms involved in the interindividual differences in opioid sensitivity would help establish p...
作者:E. Teodorov , M.F.R. Ferrari , D.R. Fior-Chadi ...
来源:[J].Brazilian Journal of Medical and Biological Research(IF 1.139), 2012, Vol.45 (10), pp.982-987DOAJ
摘要:The periaqueductal gray (PAG) has been reported to be a location for opioid regulation of pain and a potential site for behavioral selection in females. Opioid-mediated behavioral and physiological responses differ according to the activity of opioid receptor subtypes. The presen...
作者:Emily C. Eastwood , Tamara J. Phillips
来源:[J].Addiction Biology(IF 5.914), 2014, Vol.19 (3), pp.370-379Wiley
摘要:... These lines were used to determine whether opioid sensitivity and MA intake are genetically associated, because opioid‐mediated pathways influence some effects of MA . Sensitivity to the analgesic effects of the μ ‐opioid receptor ( MOP ‐r) agonist fentanyl (0.05, 0...
作者:Michael C. Montana , Lindsay Juriga , Anshuman Sharma ...
来源:[J].Anesthesiology(IF 5.163), 2019Wolters Kluwer
摘要:WHAT WE ALREADY KNOW ABOUT THIS TOPIC: Children with obstructive sleep apnea are at greater risk for postoperative hypoxia and other respiratory events as compared with children without this disorderThere is some reason to believe that children with obstructive sleep apnea may be at greater risk for opioid...

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